Genetic background modulates behavioral impairments in R6/2 mice and suggests a role for dominant genetic modifiers in Huntington’s disease pathogenesis

Variability and modification of the symptoms of Huntington’s disease (HD) are commonly observed in both patient populations and animal models of the disease. Utilizing a stable line of the R6/2 HD mouse model, the present study investigated the role of genetic background in the onset and severity of...

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Detalles Bibliográficos
Autores principales: Cowin, Randi-Michelle, Bui, Nghiem, Graham, Deanna, Green, Jennie R., Yuva-Paylor, Lisa A., Weiss, Andreas, Paylor, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357469/
https://www.ncbi.nlm.nih.gov/pubmed/22290451
http://dx.doi.org/10.1007/s00335-012-9391-5

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