TCTP in Development and Cancer

The translationally controlled tumor protein (TCTP) is highly conserved among animal species. It is widely expressed in many different tissues. It is involved in regulating many fundamental processes, such as cell proliferation and growth, apoptosis, pluripotency, and the cell cycle. Hence, it is no...

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Detalles Bibliográficos
Autores principales: Koziol, Magdalena J., Gurdon, John B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357502/
https://www.ncbi.nlm.nih.gov/pubmed/22649730
http://dx.doi.org/10.1155/2012/105203
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author Koziol, Magdalena J.
Gurdon, John B.
author_facet Koziol, Magdalena J.
Gurdon, John B.
author_sort Koziol, Magdalena J.
collection PubMed
description The translationally controlled tumor protein (TCTP) is highly conserved among animal species. It is widely expressed in many different tissues. It is involved in regulating many fundamental processes, such as cell proliferation and growth, apoptosis, pluripotency, and the cell cycle. Hence, it is not surprising that it is essential for normal development and, if misregulated, can lead to cancer. Provided herein is an overview of the diverse functions of TCTP, with a focus on development. Furthermore, we discuss possible ways by which TCTP misregulation or mutation could result in cancer.
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spelling pubmed-33575022012-05-30 TCTP in Development and Cancer Koziol, Magdalena J. Gurdon, John B. Biochem Res Int Review Article The translationally controlled tumor protein (TCTP) is highly conserved among animal species. It is widely expressed in many different tissues. It is involved in regulating many fundamental processes, such as cell proliferation and growth, apoptosis, pluripotency, and the cell cycle. Hence, it is not surprising that it is essential for normal development and, if misregulated, can lead to cancer. Provided herein is an overview of the diverse functions of TCTP, with a focus on development. Furthermore, we discuss possible ways by which TCTP misregulation or mutation could result in cancer. Hindawi Publishing Corporation 2012 2012-05-09 /pmc/articles/PMC3357502/ /pubmed/22649730 http://dx.doi.org/10.1155/2012/105203 Text en Copyright © 2012 M. J. Koziol and J. B. Gurdon. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Koziol, Magdalena J.
Gurdon, John B.
TCTP in Development and Cancer
title TCTP in Development and Cancer
title_full TCTP in Development and Cancer
title_fullStr TCTP in Development and Cancer
title_full_unstemmed TCTP in Development and Cancer
title_short TCTP in Development and Cancer
title_sort tctp in development and cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357502/
https://www.ncbi.nlm.nih.gov/pubmed/22649730
http://dx.doi.org/10.1155/2012/105203
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