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Ductal Carcinoma In Situ: What Can We Learn from Clinical Trials?
Ductal Carcinoma in situ has been diagnosed more frequently in the last few years and now accounts for approximately one-fourth of all treated breast cancers. Traditionally, this disease has been treated with total mastectomy, but conservative surgery has become increasingly used in the absence of u...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357523/ https://www.ncbi.nlm.nih.gov/pubmed/22649720 http://dx.doi.org/10.1155/2012/296829 |
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author | Fortunato, Lucio Poccia, Igor de Paula, Ugo Santini, Elena |
author_facet | Fortunato, Lucio Poccia, Igor de Paula, Ugo Santini, Elena |
author_sort | Fortunato, Lucio |
collection | PubMed |
description | Ductal Carcinoma in situ has been diagnosed more frequently in the last few years and now accounts for approximately one-fourth of all treated breast cancers. Traditionally, this disease has been treated with total mastectomy, but conservative surgery has become increasingly used in the absence of unfavourable clinical conditions, if a negative excision margin can be achieved. It is controversial whether subgroups of patients with favourable in situ tumors could be managed by conservative surgery alone, without radiation. As the disease is diagnosed more frequently in younger patients, these issues are very relevant, and much research has focused on this topic in the last two decades. We reviewed randomized trials regarding adjuvant radiation after breast-conservative surgery and compared data with available retrospective studies. |
format | Online Article Text |
id | pubmed-3357523 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33575232012-05-30 Ductal Carcinoma In Situ: What Can We Learn from Clinical Trials? Fortunato, Lucio Poccia, Igor de Paula, Ugo Santini, Elena Int J Surg Oncol Review Article Ductal Carcinoma in situ has been diagnosed more frequently in the last few years and now accounts for approximately one-fourth of all treated breast cancers. Traditionally, this disease has been treated with total mastectomy, but conservative surgery has become increasingly used in the absence of unfavourable clinical conditions, if a negative excision margin can be achieved. It is controversial whether subgroups of patients with favourable in situ tumors could be managed by conservative surgery alone, without radiation. As the disease is diagnosed more frequently in younger patients, these issues are very relevant, and much research has focused on this topic in the last two decades. We reviewed randomized trials regarding adjuvant radiation after breast-conservative surgery and compared data with available retrospective studies. Hindawi Publishing Corporation 2012 2012-05-09 /pmc/articles/PMC3357523/ /pubmed/22649720 http://dx.doi.org/10.1155/2012/296829 Text en Copyright © 2012 Lucio Fortunato et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Fortunato, Lucio Poccia, Igor de Paula, Ugo Santini, Elena Ductal Carcinoma In Situ: What Can We Learn from Clinical Trials? |
title | Ductal Carcinoma In Situ: What Can We Learn from Clinical Trials? |
title_full | Ductal Carcinoma In Situ: What Can We Learn from Clinical Trials? |
title_fullStr | Ductal Carcinoma In Situ: What Can We Learn from Clinical Trials? |
title_full_unstemmed | Ductal Carcinoma In Situ: What Can We Learn from Clinical Trials? |
title_short | Ductal Carcinoma In Situ: What Can We Learn from Clinical Trials? |
title_sort | ductal carcinoma in situ: what can we learn from clinical trials? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357523/ https://www.ncbi.nlm.nih.gov/pubmed/22649720 http://dx.doi.org/10.1155/2012/296829 |
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