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The Relationship between Heart Rate Variability and Adiposity Differs for Central and Overall Adiposity

While frank obesity is associated with reduced HRV, indicative of poorer autonomic nervous system (ANS) function, the association between body mass index (BMI) and HRV is less clear. We hypothesized that effects of adiposity on ANS are mostly mediated by visceral fat and less by subcutaneous fat; th...

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Autores principales: Windham, B. Gwen, Fumagalli, Stefano, Ble, Alessandro, Sollers, John J., Thayer, Julian F., Najjar, Samar S., Griswold, Michael E., Ferrucci, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357556/
https://www.ncbi.nlm.nih.gov/pubmed/22649714
http://dx.doi.org/10.1155/2012/149516
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author Windham, B. Gwen
Fumagalli, Stefano
Ble, Alessandro
Sollers, John J.
Thayer, Julian F.
Najjar, Samar S.
Griswold, Michael E.
Ferrucci, Luigi
author_facet Windham, B. Gwen
Fumagalli, Stefano
Ble, Alessandro
Sollers, John J.
Thayer, Julian F.
Najjar, Samar S.
Griswold, Michael E.
Ferrucci, Luigi
author_sort Windham, B. Gwen
collection PubMed
description While frank obesity is associated with reduced HRV, indicative of poorer autonomic nervous system (ANS) function, the association between body mass index (BMI) and HRV is less clear. We hypothesized that effects of adiposity on ANS are mostly mediated by visceral fat and less by subcutaneous fat; therefore, centrally distributed adipose tissue, that is, waist circumference (WC), should be more strongly associated with HRV than overall adiposity (BMI). To examine this hypothesis, we used data collected in a subset of the Baltimore Longitudinal Study of Aging to compare strength of association between HRV and WC to that of HRV and BMI. Time domain HRV variables SDNN (standard deviation of successive differences in normal-to-normal (N-N) intervals) and RMSSD (root mean square of successive differences in N-N intervals) were calculated from 24-hour Holter recordings in 159 participants (29–96 years). Increasing WC was associated with decreasing SDNN and RMSSD in younger but not older participants (P value for WC-by-age interaction = 0.003). BMI was not associated with either SDNN or RMSSD at any age. In conclusion, central adiposity may contribute to sympathetic and parasympathetic ANS declines early in life.
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spelling pubmed-33575562012-05-30 The Relationship between Heart Rate Variability and Adiposity Differs for Central and Overall Adiposity Windham, B. Gwen Fumagalli, Stefano Ble, Alessandro Sollers, John J. Thayer, Julian F. Najjar, Samar S. Griswold, Michael E. Ferrucci, Luigi J Obes Research Article While frank obesity is associated with reduced HRV, indicative of poorer autonomic nervous system (ANS) function, the association between body mass index (BMI) and HRV is less clear. We hypothesized that effects of adiposity on ANS are mostly mediated by visceral fat and less by subcutaneous fat; therefore, centrally distributed adipose tissue, that is, waist circumference (WC), should be more strongly associated with HRV than overall adiposity (BMI). To examine this hypothesis, we used data collected in a subset of the Baltimore Longitudinal Study of Aging to compare strength of association between HRV and WC to that of HRV and BMI. Time domain HRV variables SDNN (standard deviation of successive differences in normal-to-normal (N-N) intervals) and RMSSD (root mean square of successive differences in N-N intervals) were calculated from 24-hour Holter recordings in 159 participants (29–96 years). Increasing WC was associated with decreasing SDNN and RMSSD in younger but not older participants (P value for WC-by-age interaction = 0.003). BMI was not associated with either SDNN or RMSSD at any age. In conclusion, central adiposity may contribute to sympathetic and parasympathetic ANS declines early in life. Hindawi Publishing Corporation 2012 2012-05-09 /pmc/articles/PMC3357556/ /pubmed/22649714 http://dx.doi.org/10.1155/2012/149516 Text en Copyright © 2012 B. Gwen Windham et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Windham, B. Gwen
Fumagalli, Stefano
Ble, Alessandro
Sollers, John J.
Thayer, Julian F.
Najjar, Samar S.
Griswold, Michael E.
Ferrucci, Luigi
The Relationship between Heart Rate Variability and Adiposity Differs for Central and Overall Adiposity
title The Relationship between Heart Rate Variability and Adiposity Differs for Central and Overall Adiposity
title_full The Relationship between Heart Rate Variability and Adiposity Differs for Central and Overall Adiposity
title_fullStr The Relationship between Heart Rate Variability and Adiposity Differs for Central and Overall Adiposity
title_full_unstemmed The Relationship between Heart Rate Variability and Adiposity Differs for Central and Overall Adiposity
title_short The Relationship between Heart Rate Variability and Adiposity Differs for Central and Overall Adiposity
title_sort relationship between heart rate variability and adiposity differs for central and overall adiposity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357556/
https://www.ncbi.nlm.nih.gov/pubmed/22649714
http://dx.doi.org/10.1155/2012/149516
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