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The Neglected Significance of “Antioxidative Stress”

Oxidative stress arises when there is a marked imbalance between the production and removal of reactive oxygen species (ROS) in favor of the prooxidant balance, leading to potential oxidative damage. ROSs were considered traditionally to be only a toxic byproduct of aerobic metabolism. However, rece...

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Detalles Bibliográficos
Autores principales: Poljsak, B., Milisav, I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357598/
https://www.ncbi.nlm.nih.gov/pubmed/22655114
http://dx.doi.org/10.1155/2012/480895
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author Poljsak, B.
Milisav, I.
author_facet Poljsak, B.
Milisav, I.
author_sort Poljsak, B.
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description Oxidative stress arises when there is a marked imbalance between the production and removal of reactive oxygen species (ROS) in favor of the prooxidant balance, leading to potential oxidative damage. ROSs were considered traditionally to be only a toxic byproduct of aerobic metabolism. However, recently, it has become apparent that ROS might control many different physiological processes such as induction of stress response, pathogen defense, and systemic signaling. Thus, the imbalance of the increased antioxidant potential, the so-called antioxidative stress, should be as dangerous as well. Here, we synthesize increasing evidence on “antioxidative stress-induced” beneficial versus harmful roles on health, disease, and aging processes. Oxidative stress is not necessarily an un-wanted situation, since its consequences may be beneficial for many physiological reactions in cells. On the other hand, there are potentially harmful effects of “antioxidative stress,” especially in the cases of overconsumption of synthetic antioxidants. Antioxidants can neutralize ROS and decrease oxidative stress; however, this is not always beneficial in regard to disease formation or progression (of, e.g., cancer) or for delaying aging.
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spelling pubmed-33575982012-05-31 The Neglected Significance of “Antioxidative Stress” Poljsak, B. Milisav, I. Oxid Med Cell Longev Review Article Oxidative stress arises when there is a marked imbalance between the production and removal of reactive oxygen species (ROS) in favor of the prooxidant balance, leading to potential oxidative damage. ROSs were considered traditionally to be only a toxic byproduct of aerobic metabolism. However, recently, it has become apparent that ROS might control many different physiological processes such as induction of stress response, pathogen defense, and systemic signaling. Thus, the imbalance of the increased antioxidant potential, the so-called antioxidative stress, should be as dangerous as well. Here, we synthesize increasing evidence on “antioxidative stress-induced” beneficial versus harmful roles on health, disease, and aging processes. Oxidative stress is not necessarily an un-wanted situation, since its consequences may be beneficial for many physiological reactions in cells. On the other hand, there are potentially harmful effects of “antioxidative stress,” especially in the cases of overconsumption of synthetic antioxidants. Antioxidants can neutralize ROS and decrease oxidative stress; however, this is not always beneficial in regard to disease formation or progression (of, e.g., cancer) or for delaying aging. Hindawi Publishing Corporation 2012 2012-05-08 /pmc/articles/PMC3357598/ /pubmed/22655114 http://dx.doi.org/10.1155/2012/480895 Text en Copyright © 2012 B. Poljsak and I. Milisav. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Poljsak, B.
Milisav, I.
The Neglected Significance of “Antioxidative Stress”
title The Neglected Significance of “Antioxidative Stress”
title_full The Neglected Significance of “Antioxidative Stress”
title_fullStr The Neglected Significance of “Antioxidative Stress”
title_full_unstemmed The Neglected Significance of “Antioxidative Stress”
title_short The Neglected Significance of “Antioxidative Stress”
title_sort neglected significance of “antioxidative stress”
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357598/
https://www.ncbi.nlm.nih.gov/pubmed/22655114
http://dx.doi.org/10.1155/2012/480895
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