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Long term outcome of acquired food allergy in pediatric liver recipients: a single center experience

Food induced sensitization has been reported in pediatric liver recipients. However long term follow up has not been established so far. We report here our experience regarding 3 pediatric patients who developed acquired food allergy after liver transplantation. The first patient suffered from persi...

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Autores principales: Mavroudi, Antigoni, Xinias, Ioannis, Deligiannidis, Aristidis, Parapanissiou, Efthimia, Imvrios, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357619/
https://www.ncbi.nlm.nih.gov/pubmed/22690312
http://dx.doi.org/10.4081/pr.2012.e6
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author Mavroudi, Antigoni
Xinias, Ioannis
Deligiannidis, Aristidis
Parapanissiou, Efthimia
Imvrios, George
author_facet Mavroudi, Antigoni
Xinias, Ioannis
Deligiannidis, Aristidis
Parapanissiou, Efthimia
Imvrios, George
author_sort Mavroudi, Antigoni
collection PubMed
description Food induced sensitization has been reported in pediatric liver recipients. However long term follow up has not been established so far. We report here our experience regarding 3 pediatric patients who developed acquired food allergy after liver transplantation. The first patient suffered from persistent diarrhea and eczema. The second one presented with abdominal pain with no signs of rejection, abdominal discomfort, vomiting when ingesting milk proteins and responded well to the elimination diet. The third patient presented with facial angioedema and hoarseness of voice. She had multiple food allergies and reacted to milk, egg and sesame. All the patients had elevated total Immunoglobulin E (IgE) and elevated specific IgE antibodies to the implicated food allergens. The first patient presented clinical manifestations of allergy when she was 19 months old. The second patient became allergic at the age of 16 and the third patient at the age of 3. The symptoms of food allergy persisted for 8 years in the first case and for 2 years in the other two cases. Low levels of specific IgE antibodies to the implicated food allergens and an enhanced T-helper 1 cell immune response toward interferon-gamma production were markers of tolerance acquisition. The long term prognosis in our cases was excellent. Food allergy resolved in all the patients. The long term prognosis of acquired food allergy after liver transplantation is currently obscure. More studies would be needed including greater number of patients to determine whether acquired food allergy is transient in pediatric liver recipients.
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spelling pubmed-33576192012-06-11 Long term outcome of acquired food allergy in pediatric liver recipients: a single center experience Mavroudi, Antigoni Xinias, Ioannis Deligiannidis, Aristidis Parapanissiou, Efthimia Imvrios, George Pediatr Rep Case Report Food induced sensitization has been reported in pediatric liver recipients. However long term follow up has not been established so far. We report here our experience regarding 3 pediatric patients who developed acquired food allergy after liver transplantation. The first patient suffered from persistent diarrhea and eczema. The second one presented with abdominal pain with no signs of rejection, abdominal discomfort, vomiting when ingesting milk proteins and responded well to the elimination diet. The third patient presented with facial angioedema and hoarseness of voice. She had multiple food allergies and reacted to milk, egg and sesame. All the patients had elevated total Immunoglobulin E (IgE) and elevated specific IgE antibodies to the implicated food allergens. The first patient presented clinical manifestations of allergy when she was 19 months old. The second patient became allergic at the age of 16 and the third patient at the age of 3. The symptoms of food allergy persisted for 8 years in the first case and for 2 years in the other two cases. Low levels of specific IgE antibodies to the implicated food allergens and an enhanced T-helper 1 cell immune response toward interferon-gamma production were markers of tolerance acquisition. The long term prognosis in our cases was excellent. Food allergy resolved in all the patients. The long term prognosis of acquired food allergy after liver transplantation is currently obscure. More studies would be needed including greater number of patients to determine whether acquired food allergy is transient in pediatric liver recipients. PAGEPress Publications 2012-01-30 /pmc/articles/PMC3357619/ /pubmed/22690312 http://dx.doi.org/10.4081/pr.2012.e6 Text en ©Copyright A. Mavroudi et al., 2012 This work is licensed under a Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0). Licensee PAGEPress, Italy
spellingShingle Case Report
Mavroudi, Antigoni
Xinias, Ioannis
Deligiannidis, Aristidis
Parapanissiou, Efthimia
Imvrios, George
Long term outcome of acquired food allergy in pediatric liver recipients: a single center experience
title Long term outcome of acquired food allergy in pediatric liver recipients: a single center experience
title_full Long term outcome of acquired food allergy in pediatric liver recipients: a single center experience
title_fullStr Long term outcome of acquired food allergy in pediatric liver recipients: a single center experience
title_full_unstemmed Long term outcome of acquired food allergy in pediatric liver recipients: a single center experience
title_short Long term outcome of acquired food allergy in pediatric liver recipients: a single center experience
title_sort long term outcome of acquired food allergy in pediatric liver recipients: a single center experience
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357619/
https://www.ncbi.nlm.nih.gov/pubmed/22690312
http://dx.doi.org/10.4081/pr.2012.e6
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