Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers

Multidrug resistance (MDR) remains a primary hindrance to curative cancer therapy. Thus, introduction of novel strategies to overcome MDR is of paramount therapeutic significance. Sequestration of chemotherapeutics in lysosomes is an established mechanism of drug resistance. Here, we show that MDR c...

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Detalles Bibliográficos
Autores principales: Adar, Y, Stark, M, Bram, E E, Nowak-Sliwinska, P, van den Bergh, H, Szewczyk, G, Sarna, T, Skladanowski, A, Griffioen, A W, Assaraf, Y G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358008/
https://www.ncbi.nlm.nih.gov/pubmed/22476101
http://dx.doi.org/10.1038/cddis.2012.30

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358008/
https://www.ncbi.nlm.nih.gov/pubmed/22476101
http://dx.doi.org/10.1038/cddis.2012.30

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