Cargando…

Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers

Multidrug resistance (MDR) remains a primary hindrance to curative cancer therapy. Thus, introduction of novel strategies to overcome MDR is of paramount therapeutic significance. Sequestration of chemotherapeutics in lysosomes is an established mechanism of drug resistance. Here, we show that MDR c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Adar, Y, Stark, M, Bram, E E, Nowak-Sliwinska, P, van den Bergh, H, Szewczyk, G, Sarna, T, Skladanowski, A, Griffioen, A W, Assaraf, Y G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358008/ https://www.ncbi.nlm.nih.gov/pubmed/22476101 http://dx.doi.org/10.1038/cddis.2012.30

Ejemplares similares

Gallium Mesoporphyrin IX-Mediated Photodestruction: A Pharmacological Trojan Horse Strategy To Eliminate Multidrug-Resistant Staphylococcus aureus
por: Michalska, Klaudia, et al.
Publicado: (2022)

Photodynamic Inactivation of Candida albicans with Imidazoacridinones: Influence of Irradiance, Photosensitizer Uptake and Reactive Oxygen Species Generation
por: Taraszkiewicz, Aleksandra, et al.
Publicado: (2015)

Overcoming Multidrug Resistance via Photodestruction of ABCG2-Rich Extracellular Vesicles Sequestering Photosensitive Chemotherapeutics
por: Goler-Baron, Vicky, et al.
Publicado: (2012)

Photoactivation of lysosomally sequestered sunitinib after angiostatic treatment causes vascular occlusion and enhances tumor growth inhibition
por: Nowak-Sliwinska, P, et al.
Publicado: (2015)

Invisible Trojan-horse attack
por: Sajeed, Shihan, et al.
Publicado: (2017)

HIV and Mature Dendritic Cells: Trojan Exosomes Riding the Trojan Horse?
por: Izquierdo-Useros, Nuria, et al.
Publicado: (2010)

Two Distinct Lysosomal Targeting Strategies Afford Trojan Horse Antibodies With Pan-Filovirus Activity
por: Wirchnianski, Ariel S., et al.
Publicado: (2021)

When plants are Trojan horses for viruses
por: Sáez, Cristina, et al.
Publicado: (2022)

FINE STRUCTURAL CHANGES IN PROPLASTIDS DURING PHOTODESTRUCTION OF PIGMENTS
por: Klein, Shimon, et al.
Publicado: (1964)

Correcting for photodestruction in super-resolution optical fluctuation imaging
por: Peeters, Yves, et al.
Publicado: (2017)

Photodestruction of Diatomic Molecular Ions: Laboratory and Astrophysical Application
por: Srećković, Vladimir A., et al.
Publicado: (2020)

Natural Trojan horse inhibitors of aminoacyl-tRNA synthetases
por: Travin, Dmitrii Y., et al.
Publicado: (2021)

Prairie Dog: Cuddly Pet or Trojan Horse?
por: Azad, Abdu F.
Publicado: (2004)

Siderophores as “Trojan Horses”: tackling multidrug resistance?
por: de Carvalho, Carla C. C. R., et al.
Publicado: (2014)

Publisher Correction: Invisible Trojan-horse attack
por: Sajeed, Shihan, et al.
Publicado: (2017)

Trojan‐Horse‐Like Stimuli‐Responsive Microcapsules
por: Mou, Chuan‐Lin, et al.
Publicado: (2018)

Macrophages: a Trojan horse in COVID-19?
por: Park, Matthew D.
Publicado: (2020)

Are Hematologic Patients Trojan Horse for COVID-19?
por: Kılıçaslan, Emrah, et al.
Publicado: (2021)

Macrophages and Monocytes: “Trojan Horses” in COVID-19
por: Percivalle, Elena, et al.
Publicado: (2021)

Ducks: The “Trojan Horses” of H5N1 influenza
por: Kim, Jeong‐Ki, et al.
Publicado: (2009)

Silicon particles as trojan horses for potential cancer therapy
por: Fenollosa, Roberto, et al.
Publicado: (2014)

The “TROJAN HORSE” of a Dental Visit – Synovial Sarcoma
por: Mortha, Neeharika, et al.
Publicado: (2018)

The Trojan horse - neuroinflammatory impact of T cells in neurodegenerative diseases
por: Sommer, Annika, et al.
Publicado: (2017)

Extracellular Citrate Is a Trojan Horse for Cancer Cells
por: Petillo, Agata, et al.
Publicado: (2020)

Platelets in Viral Infections – Brave Soldiers or Trojan Horses
por: Schrottmaier, Waltraud C., et al.
Publicado: (2022)

Metabolic Reprogramming in Gastric Cancer: Trojan Horse Effect
por: Bin, Yu-Ling, et al.
Publicado: (2022)

Brain gene therapy with Trojan horse lipid nanoparticles
por: Pardridge, William M.
Publicado: (2023)

Wet-Spun Trojan Horse Cell Constructs for Engineering Muscle
por: Quigley, Anita F., et al.
Publicado: (2020)

Potential Tools for Eradicating HIV Reservoirs in the Brain: Development of Trojan Horse Prodrugs for the Inhibition of P-Glycoprotein with Anti-HIV-1 Activity
por: Agrawal, Neha, et al.
Publicado: (2019)

Bone mineral: A trojan horse for bone cancers. Efficient mitochondria targeted delivery and tumor eradication with nano hydroxyapatite containing doxorubicin
por: Liu, Yang, et al.
Publicado: (2022)

Tyrosine-Phosphorylated Bacterial Proteins: Trojan Horses for the Host Cell
por: Covacci, Antonello, et al.
Publicado: (2000)

A peptidic hydrogel that may behave as a “Trojan Horse”
por: Castellucci, Nicola, et al.
Publicado: (2013)

Riding the Trojan horse: combating pest insects with their own symbionts
por: Jurkevitch, Edouard
Publicado: (2011)

The “Trojan Horse” Approach to Tumor Immunotherapy: Targeting the Tumor Microenvironment
por: Nelson, Delia, et al.
Publicado: (2014)

Senescence and NFκB: A trojan horse in tumors?
por: Crescenzi, Elvira, et al.
Publicado: (2012)

Lactose as a “Trojan Horse” for Quantum Dot Cell Transport**
por: Benito-Alifonso, David, et al.
Publicado: (2014)

Is tapentadol a potential Trojan horse in the postdextropropoxyphene era in India?
por: Basu, Aniruddha, et al.
Publicado: (2018)

False friends: Phagocytes as Trojan horses in microbial brain infections
por: Santiago-Tirado, Felipe H., et al.
Publicado: (2017)

Infectious Threats, the Intestinal Barrier, and Its Trojan Horse: Dysbiosis
por: Iacob, Simona, et al.
Publicado: (2019)

Neutrophils as Trojan Horse Vehicles for Brucella abortus Macrophage Infection
por: Gutiérrez-Jiménez, Cristina, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_7cip1dn1skbftnv7li4ptgd1se