Inhibition of ER stress-mediated apoptosis in macrophages by nuclear-cytoplasmic relocalization of eEF1A by the HIV-1 Nef protein

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HIV-1 Nef protein has key roles at almost all stages of the viral life cycle. We assessed the role of the Nef/eEF1A (eukaryotic translation elongation factor 1-alpha) complex in nucleocytoplasmic shuttling in primary human macrophages. Nuclear retention experiments and inhibition of the exportin-t (...

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Detalles Bibliográficos
Autores principales: Abbas, W, Khan, K A, Tripathy, M K, Dichamp, I, Keita, M, Rohr, O, Herbein, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358010/
https://www.ncbi.nlm.nih.gov/pubmed/22476100
http://dx.doi.org/10.1038/cddis.2012.32

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