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Characterization of Virulent West Nile Virus Kunjin Strain, Australia, 2011
To determine the cause of an unprecedented outbreak of encephalitis among horses in New South Wales, Australia, in 2011, we performed genomic sequencing of viruses isolated from affected horses and mosquitoes. Results showed that most of the cases were caused by a variant West Nile virus (WNV) strai...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358055/ https://www.ncbi.nlm.nih.gov/pubmed/22516173 http://dx.doi.org/10.3201/eid1805.111720 |
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author | Frost, Melinda J. Zhang, Jing Edmonds, Judith H. Prow, Natalie A. Gu, Xingnian Davis, Rodney Hornitzky, Christine Arzey, Kathleen E. Finlaison, Deborah Hick, Paul Read, Andrew Hobson-Peters, Jody May, Fiona J. Doggett, Stephen L. Haniotis, John Russell, Richard C. Hall, Roy A. Khromykh, Alexander A. Kirkland, Peter D. |
author_facet | Frost, Melinda J. Zhang, Jing Edmonds, Judith H. Prow, Natalie A. Gu, Xingnian Davis, Rodney Hornitzky, Christine Arzey, Kathleen E. Finlaison, Deborah Hick, Paul Read, Andrew Hobson-Peters, Jody May, Fiona J. Doggett, Stephen L. Haniotis, John Russell, Richard C. Hall, Roy A. Khromykh, Alexander A. Kirkland, Peter D. |
author_sort | Frost, Melinda J. |
collection | PubMed |
description | To determine the cause of an unprecedented outbreak of encephalitis among horses in New South Wales, Australia, in 2011, we performed genomic sequencing of viruses isolated from affected horses and mosquitoes. Results showed that most of the cases were caused by a variant West Nile virus (WNV) strain, WNV(NSW2011), that is most closely related to WNV Kunjin (WNV(KUN)), the indigenous WNV strain in Australia. Studies in mouse models for WNV pathogenesis showed that WNV(NSW2011) is substantially more neuroinvasive than the prototype WNV(KUN) strain. In WNV(NSW2011), this apparent increase in virulence over that of the prototype strain correlated with at least 2 known markers of WNV virulence that are not found in WNV(KUN). Additional studies are needed to determine the relationship of the WNV(NSW2011) strain to currently and previously circulating WNV(KUN) strains and to confirm the cause of the increased virulence of this emerging WNV strain. |
format | Online Article Text |
id | pubmed-3358055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-33580552012-05-29 Characterization of Virulent West Nile Virus Kunjin Strain, Australia, 2011 Frost, Melinda J. Zhang, Jing Edmonds, Judith H. Prow, Natalie A. Gu, Xingnian Davis, Rodney Hornitzky, Christine Arzey, Kathleen E. Finlaison, Deborah Hick, Paul Read, Andrew Hobson-Peters, Jody May, Fiona J. Doggett, Stephen L. Haniotis, John Russell, Richard C. Hall, Roy A. Khromykh, Alexander A. Kirkland, Peter D. Emerg Infect Dis Research To determine the cause of an unprecedented outbreak of encephalitis among horses in New South Wales, Australia, in 2011, we performed genomic sequencing of viruses isolated from affected horses and mosquitoes. Results showed that most of the cases were caused by a variant West Nile virus (WNV) strain, WNV(NSW2011), that is most closely related to WNV Kunjin (WNV(KUN)), the indigenous WNV strain in Australia. Studies in mouse models for WNV pathogenesis showed that WNV(NSW2011) is substantially more neuroinvasive than the prototype WNV(KUN) strain. In WNV(NSW2011), this apparent increase in virulence over that of the prototype strain correlated with at least 2 known markers of WNV virulence that are not found in WNV(KUN). Additional studies are needed to determine the relationship of the WNV(NSW2011) strain to currently and previously circulating WNV(KUN) strains and to confirm the cause of the increased virulence of this emerging WNV strain. Centers for Disease Control and Prevention 2012-05 /pmc/articles/PMC3358055/ /pubmed/22516173 http://dx.doi.org/10.3201/eid1805.111720 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Frost, Melinda J. Zhang, Jing Edmonds, Judith H. Prow, Natalie A. Gu, Xingnian Davis, Rodney Hornitzky, Christine Arzey, Kathleen E. Finlaison, Deborah Hick, Paul Read, Andrew Hobson-Peters, Jody May, Fiona J. Doggett, Stephen L. Haniotis, John Russell, Richard C. Hall, Roy A. Khromykh, Alexander A. Kirkland, Peter D. Characterization of Virulent West Nile Virus Kunjin Strain, Australia, 2011 |
title | Characterization of Virulent West Nile Virus Kunjin Strain, Australia, 2011 |
title_full | Characterization of Virulent West Nile Virus Kunjin Strain, Australia, 2011 |
title_fullStr | Characterization of Virulent West Nile Virus Kunjin Strain, Australia, 2011 |
title_full_unstemmed | Characterization of Virulent West Nile Virus Kunjin Strain, Australia, 2011 |
title_short | Characterization of Virulent West Nile Virus Kunjin Strain, Australia, 2011 |
title_sort | characterization of virulent west nile virus kunjin strain, australia, 2011 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358055/ https://www.ncbi.nlm.nih.gov/pubmed/22516173 http://dx.doi.org/10.3201/eid1805.111720 |
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