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Novel Strain of Andes Virus Associated with Fatal Human Infection, Central Bolivia
To better describe the genetic diversity of hantaviruses associated with human illness in South America, we screened blood samples from febrile patients in Chapare Province in central Bolivia during 2008–2009 for recent hantavirus infection. Hantavirus RNA was detected in 3 patients, including 1 who...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358070/ https://www.ncbi.nlm.nih.gov/pubmed/22515983 http://dx.doi.org/10.3201/eid1805.111111 |
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author | Cruz, Cristhopher D. Forshey, Brett M. Vallejo, Efrain Agudo, Roberto Vargas, Jorge Blazes, David L. Guevara, Carolina Laguna-Torres, V. Alberto Halsey, Eric S. Kochel, Tadeusz J. |
author_facet | Cruz, Cristhopher D. Forshey, Brett M. Vallejo, Efrain Agudo, Roberto Vargas, Jorge Blazes, David L. Guevara, Carolina Laguna-Torres, V. Alberto Halsey, Eric S. Kochel, Tadeusz J. |
author_sort | Cruz, Cristhopher D. |
collection | PubMed |
description | To better describe the genetic diversity of hantaviruses associated with human illness in South America, we screened blood samples from febrile patients in Chapare Province in central Bolivia during 2008–2009 for recent hantavirus infection. Hantavirus RNA was detected in 3 patients, including 1 who died. Partial RNA sequences of small and medium segments from the 3 patients were most closely related to Andes virus lineages but distinct (<90% nt identity) from reported strains. A survey for IgG against hantaviruses among residents of Chapare Province indicated that 12.2% of the population had past exposure to >1 hantaviruses; the highest prevalence was among agricultural workers. Because of the high level of human exposure to hantavirus strains and the severity of resulting disease, additional studies are warranted to determine the reservoirs, ecologic range, and public health effect of this novel strain of hantavirus. |
format | Online Article Text |
id | pubmed-3358070 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-33580702012-05-29 Novel Strain of Andes Virus Associated with Fatal Human Infection, Central Bolivia Cruz, Cristhopher D. Forshey, Brett M. Vallejo, Efrain Agudo, Roberto Vargas, Jorge Blazes, David L. Guevara, Carolina Laguna-Torres, V. Alberto Halsey, Eric S. Kochel, Tadeusz J. Emerg Infect Dis Research To better describe the genetic diversity of hantaviruses associated with human illness in South America, we screened blood samples from febrile patients in Chapare Province in central Bolivia during 2008–2009 for recent hantavirus infection. Hantavirus RNA was detected in 3 patients, including 1 who died. Partial RNA sequences of small and medium segments from the 3 patients were most closely related to Andes virus lineages but distinct (<90% nt identity) from reported strains. A survey for IgG against hantaviruses among residents of Chapare Province indicated that 12.2% of the population had past exposure to >1 hantaviruses; the highest prevalence was among agricultural workers. Because of the high level of human exposure to hantavirus strains and the severity of resulting disease, additional studies are warranted to determine the reservoirs, ecologic range, and public health effect of this novel strain of hantavirus. Centers for Disease Control and Prevention 2012-05 /pmc/articles/PMC3358070/ /pubmed/22515983 http://dx.doi.org/10.3201/eid1805.111111 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Cruz, Cristhopher D. Forshey, Brett M. Vallejo, Efrain Agudo, Roberto Vargas, Jorge Blazes, David L. Guevara, Carolina Laguna-Torres, V. Alberto Halsey, Eric S. Kochel, Tadeusz J. Novel Strain of Andes Virus Associated with Fatal Human Infection, Central Bolivia |
title | Novel Strain of Andes Virus Associated with Fatal Human Infection, Central Bolivia |
title_full | Novel Strain of Andes Virus Associated with Fatal Human Infection, Central Bolivia |
title_fullStr | Novel Strain of Andes Virus Associated with Fatal Human Infection, Central Bolivia |
title_full_unstemmed | Novel Strain of Andes Virus Associated with Fatal Human Infection, Central Bolivia |
title_short | Novel Strain of Andes Virus Associated with Fatal Human Infection, Central Bolivia |
title_sort | novel strain of andes virus associated with fatal human infection, central bolivia |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358070/ https://www.ncbi.nlm.nih.gov/pubmed/22515983 http://dx.doi.org/10.3201/eid1805.111111 |
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