Temporal Trends in Bordetella pertussis Populations, Denmark, 1949–2010

We used multilocus variable-number tandem repeat analysis and multiple antigen sequence typing to characterize isolates of Bordetella pertussis strains circulating in Denmark during periods with and without pertussis vaccination coverage. Our results show substantial shifts in the B. pertussis popul...

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Detalles Bibliográficos
Autores principales: Petersen, Randi Føns, Dalby, Tine, Dragsted, Ditte Marie, Mooi, Frits, Lambertsen, Lotte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358084/
https://www.ncbi.nlm.nih.gov/pubmed/22515990
http://dx.doi.org/10.3201/eid1805.110812
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author Petersen, Randi Føns
Dalby, Tine
Dragsted, Ditte Marie
Mooi, Frits
Lambertsen, Lotte
author_facet Petersen, Randi Føns
Dalby, Tine
Dragsted, Ditte Marie
Mooi, Frits
Lambertsen, Lotte
author_sort Petersen, Randi Føns
collection PubMed
description We used multilocus variable-number tandem repeat analysis and multiple antigen sequence typing to characterize isolates of Bordetella pertussis strains circulating in Denmark during periods with and without pertussis vaccination coverage. Our results show substantial shifts in the B. pertussis population over time and a reduction in genetic diversity. These changes might have resulted from the introduction of pertussis vaccines in Denmark and other parts of Europe. The predominant strains currently circulating in Denmark resemble those in other European countries.
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spelling pubmed-33580842012-05-29 Temporal Trends in Bordetella pertussis Populations, Denmark, 1949–2010 Petersen, Randi Føns Dalby, Tine Dragsted, Ditte Marie Mooi, Frits Lambertsen, Lotte Emerg Infect Dis Research We used multilocus variable-number tandem repeat analysis and multiple antigen sequence typing to characterize isolates of Bordetella pertussis strains circulating in Denmark during periods with and without pertussis vaccination coverage. Our results show substantial shifts in the B. pertussis population over time and a reduction in genetic diversity. These changes might have resulted from the introduction of pertussis vaccines in Denmark and other parts of Europe. The predominant strains currently circulating in Denmark resemble those in other European countries. Centers for Disease Control and Prevention 2012-05 /pmc/articles/PMC3358084/ /pubmed/22515990 http://dx.doi.org/10.3201/eid1805.110812 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Petersen, Randi Føns
Dalby, Tine
Dragsted, Ditte Marie
Mooi, Frits
Lambertsen, Lotte
Temporal Trends in Bordetella pertussis Populations, Denmark, 1949–2010
title Temporal Trends in Bordetella pertussis Populations, Denmark, 1949–2010
title_full Temporal Trends in Bordetella pertussis Populations, Denmark, 1949–2010
title_fullStr Temporal Trends in Bordetella pertussis Populations, Denmark, 1949–2010
title_full_unstemmed Temporal Trends in Bordetella pertussis Populations, Denmark, 1949–2010
title_short Temporal Trends in Bordetella pertussis Populations, Denmark, 1949–2010
title_sort temporal trends in bordetella pertussis populations, denmark, 1949–2010
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358084/
https://www.ncbi.nlm.nih.gov/pubmed/22515990
http://dx.doi.org/10.3201/eid1805.110812
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