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Intrafamilial Circulation of Tropheryma whipplei, France
Tropheryma whipplei, which causes Whipple disease, has been detected in 4% of fecal samples from the general adult population of France. To identify T. whipplei within families, we conducted serologic and molecular studies, including genotyping, on saliva, feces, and serum from 74 relatives of 13 pa...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Centers for Disease Control and Prevention
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358147/ https://www.ncbi.nlm.nih.gov/pubmed/22608161 http://dx.doi.org/10.3201/eid1806.111038 |
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author | Fenollar, Florence Keita, Alpha K. Buffet, Sylvain Raoult, Didier |
author_facet | Fenollar, Florence Keita, Alpha K. Buffet, Sylvain Raoult, Didier |
author_sort | Fenollar, Florence |
collection | PubMed |
description | Tropheryma whipplei, which causes Whipple disease, has been detected in 4% of fecal samples from the general adult population of France. To identify T. whipplei within families, we conducted serologic and molecular studies, including genotyping, on saliva, feces, and serum from 74 relatives of 13 patients with classic Whipple disease, 5 with localized chronic T. whipplei infection, and 3 carriers. Seroprevalence was determined by Western blot and compared with 300 persons from the general population. We detected T. whipplei in 24 (38%) of 64 fecal samples and 7 (10%) of 70 saliva samples from relatives but found no difference between persons related by genetics and marriage. The same circulating genotype occurred significantly more often in families than in other persons. Seroprevalence was higher among relatives (23 [77%] of 30) than in the general population (143 [48%] of 300). The high prevalence of T. whipplei within families suggests intrafamilial circulation. |
format | Online Article Text |
id | pubmed-3358147 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-33581472012-06-01 Intrafamilial Circulation of Tropheryma whipplei, France Fenollar, Florence Keita, Alpha K. Buffet, Sylvain Raoult, Didier Emerg Infect Dis Research Tropheryma whipplei, which causes Whipple disease, has been detected in 4% of fecal samples from the general adult population of France. To identify T. whipplei within families, we conducted serologic and molecular studies, including genotyping, on saliva, feces, and serum from 74 relatives of 13 patients with classic Whipple disease, 5 with localized chronic T. whipplei infection, and 3 carriers. Seroprevalence was determined by Western blot and compared with 300 persons from the general population. We detected T. whipplei in 24 (38%) of 64 fecal samples and 7 (10%) of 70 saliva samples from relatives but found no difference between persons related by genetics and marriage. The same circulating genotype occurred significantly more often in families than in other persons. Seroprevalence was higher among relatives (23 [77%] of 30) than in the general population (143 [48%] of 300). The high prevalence of T. whipplei within families suggests intrafamilial circulation. Centers for Disease Control and Prevention 2012-06 /pmc/articles/PMC3358147/ /pubmed/22608161 http://dx.doi.org/10.3201/eid1806.111038 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Fenollar, Florence Keita, Alpha K. Buffet, Sylvain Raoult, Didier Intrafamilial Circulation of Tropheryma whipplei, France |
title | Intrafamilial Circulation of Tropheryma whipplei, France |
title_full | Intrafamilial Circulation of Tropheryma whipplei, France |
title_fullStr | Intrafamilial Circulation of Tropheryma whipplei, France |
title_full_unstemmed | Intrafamilial Circulation of Tropheryma whipplei, France |
title_short | Intrafamilial Circulation of Tropheryma whipplei, France |
title_sort | intrafamilial circulation of tropheryma whipplei, france |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358147/ https://www.ncbi.nlm.nih.gov/pubmed/22608161 http://dx.doi.org/10.3201/eid1806.111038 |
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