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Intrafamilial Circulation of Tropheryma whipplei, France

Tropheryma whipplei, which causes Whipple disease, has been detected in 4% of fecal samples from the general adult population of France. To identify T. whipplei within families, we conducted serologic and molecular studies, including genotyping, on saliva, feces, and serum from 74 relatives of 13 pa...

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Autores principales: Fenollar, Florence, Keita, Alpha K., Buffet, Sylvain, Raoult, Didier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358147/
https://www.ncbi.nlm.nih.gov/pubmed/22608161
http://dx.doi.org/10.3201/eid1806.111038
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author Fenollar, Florence
Keita, Alpha K.
Buffet, Sylvain
Raoult, Didier
author_facet Fenollar, Florence
Keita, Alpha K.
Buffet, Sylvain
Raoult, Didier
author_sort Fenollar, Florence
collection PubMed
description Tropheryma whipplei, which causes Whipple disease, has been detected in 4% of fecal samples from the general adult population of France. To identify T. whipplei within families, we conducted serologic and molecular studies, including genotyping, on saliva, feces, and serum from 74 relatives of 13 patients with classic Whipple disease, 5 with localized chronic T. whipplei infection, and 3 carriers. Seroprevalence was determined by Western blot and compared with 300 persons from the general population. We detected T. whipplei in 24 (38%) of 64 fecal samples and 7 (10%) of 70 saliva samples from relatives but found no difference between persons related by genetics and marriage. The same circulating genotype occurred significantly more often in families than in other persons. Seroprevalence was higher among relatives (23 [77%] of 30) than in the general population (143 [48%] of 300). The high prevalence of T. whipplei within families suggests intrafamilial circulation.
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spelling pubmed-33581472012-06-01 Intrafamilial Circulation of Tropheryma whipplei, France Fenollar, Florence Keita, Alpha K. Buffet, Sylvain Raoult, Didier Emerg Infect Dis Research Tropheryma whipplei, which causes Whipple disease, has been detected in 4% of fecal samples from the general adult population of France. To identify T. whipplei within families, we conducted serologic and molecular studies, including genotyping, on saliva, feces, and serum from 74 relatives of 13 patients with classic Whipple disease, 5 with localized chronic T. whipplei infection, and 3 carriers. Seroprevalence was determined by Western blot and compared with 300 persons from the general population. We detected T. whipplei in 24 (38%) of 64 fecal samples and 7 (10%) of 70 saliva samples from relatives but found no difference between persons related by genetics and marriage. The same circulating genotype occurred significantly more often in families than in other persons. Seroprevalence was higher among relatives (23 [77%] of 30) than in the general population (143 [48%] of 300). The high prevalence of T. whipplei within families suggests intrafamilial circulation. Centers for Disease Control and Prevention 2012-06 /pmc/articles/PMC3358147/ /pubmed/22608161 http://dx.doi.org/10.3201/eid1806.111038 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Fenollar, Florence
Keita, Alpha K.
Buffet, Sylvain
Raoult, Didier
Intrafamilial Circulation of Tropheryma whipplei, France
title Intrafamilial Circulation of Tropheryma whipplei, France
title_full Intrafamilial Circulation of Tropheryma whipplei, France
title_fullStr Intrafamilial Circulation of Tropheryma whipplei, France
title_full_unstemmed Intrafamilial Circulation of Tropheryma whipplei, France
title_short Intrafamilial Circulation of Tropheryma whipplei, France
title_sort intrafamilial circulation of tropheryma whipplei, france
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358147/
https://www.ncbi.nlm.nih.gov/pubmed/22608161
http://dx.doi.org/10.3201/eid1806.111038
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