Inhibition of Serine Palmitoyl Transferase I Reduces Cardiac Ceramide Levels and Increases Glycolysis Rates following Diet-Induced Insulin Resistance

OBJECTIVE: Diet-induced obesity (DIO) leads to an accumulation of intra-myocardial lipid metabolites implicated in causing cardiac insulin resistance and contractile dysfunction. One such metabolite is ceramide, and our aim was to determine the effects of inhibiting de novo ceramide synthesis on car...

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Detalles Bibliográficos
Autores principales: Ussher, John R., Folmes, Clifford D. L., Keung, Wendy, Fillmore, Natasha, Jaswal, Jagdip S., Cadete, Virgilio J., Beker, Donna L., Lam, Victoria H., Zhang, Liyan, Lopaschuk, Gary D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358297/
https://www.ncbi.nlm.nih.gov/pubmed/22629445
http://dx.doi.org/10.1371/journal.pone.0037703

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