Cargando…

Methadone-Mediated Autonomic Functioning of Male Patients with Heroin Dependence: The Influence of Borderline Personality Pattern

BACKGROUND: We hypothesize that the population with borderline personality shows different autonomic response to methadone compared to individuals with other personalities. This study applies heart rate variability (HRV) measurements and the Tridimensional Personality Questionnaire (TPQ) to examine...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Wei-Lieh, Lin, Yu-Hsuan, Kuo, Terry B. J., Chang, Li-Ren, Chen, Ying-Zai, Yang, Cheryl C. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358307/
https://www.ncbi.nlm.nih.gov/pubmed/22629400
http://dx.doi.org/10.1371/journal.pone.0037464
_version_ 1782233771624366080
author Huang, Wei-Lieh
Lin, Yu-Hsuan
Kuo, Terry B. J.
Chang, Li-Ren
Chen, Ying-Zai
Yang, Cheryl C. H.
author_facet Huang, Wei-Lieh
Lin, Yu-Hsuan
Kuo, Terry B. J.
Chang, Li-Ren
Chen, Ying-Zai
Yang, Cheryl C. H.
author_sort Huang, Wei-Lieh
collection PubMed
description BACKGROUND: We hypothesize that the population with borderline personality shows different autonomic response to methadone compared to individuals with other personalities. This study applies heart rate variability (HRV) measurements and the Tridimensional Personality Questionnaire (TPQ) to examine this hypothesis. METHODOLOGY/PRINCIPAL FINDINGS: Forty-four male patients with heroin dependence were recruited from a methadone maintenance treatment program. Eight personality patterns were classified according to the TPQ norm used in Taiwan. The borderline pattern (BP, composed of high novelty seeking, high harm avoidance and low reward dependence) and the other personality patterns (OP) were separated into two groups. We compared the HRV profiles between the BP and OP groups. Correlation and regression analysis were performed to clarify relationship between HRV differences and the borderline index (BI, a new concept defined by us, which is calculated as novelty seeking + harm avoidance – reward dependence). The HRV targets investigated included low frequency (LF) power, high frequency (HF) power, total power (TP), normalized LF (LF%), and LF/HF. No baseline HRV parameters showed any inter-group difference. The BP group had a significantly lower ΔHF and a higher ΔLF/HF than the OP group. The personality dimension, reward dependence, showed a negative correlation with ΔLF/HF and ΔLF%. BI was negatively correlated with ΔHF and positively correlated with ΔLF/HF and ΔLF%. CONCLUSIONS/SIGNIFICANCE: Borderline personality individuals show increased sympathetic activity and decreased parasympathetic activity compared to other personalities after taking methadone. The results support the hypothesis that there is an interaction between borderline personality and autonomic modulation.
format Online
Article
Text
id pubmed-3358307
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-33583072012-05-24 Methadone-Mediated Autonomic Functioning of Male Patients with Heroin Dependence: The Influence of Borderline Personality Pattern Huang, Wei-Lieh Lin, Yu-Hsuan Kuo, Terry B. J. Chang, Li-Ren Chen, Ying-Zai Yang, Cheryl C. H. PLoS One Research Article BACKGROUND: We hypothesize that the population with borderline personality shows different autonomic response to methadone compared to individuals with other personalities. This study applies heart rate variability (HRV) measurements and the Tridimensional Personality Questionnaire (TPQ) to examine this hypothesis. METHODOLOGY/PRINCIPAL FINDINGS: Forty-four male patients with heroin dependence were recruited from a methadone maintenance treatment program. Eight personality patterns were classified according to the TPQ norm used in Taiwan. The borderline pattern (BP, composed of high novelty seeking, high harm avoidance and low reward dependence) and the other personality patterns (OP) were separated into two groups. We compared the HRV profiles between the BP and OP groups. Correlation and regression analysis were performed to clarify relationship between HRV differences and the borderline index (BI, a new concept defined by us, which is calculated as novelty seeking + harm avoidance – reward dependence). The HRV targets investigated included low frequency (LF) power, high frequency (HF) power, total power (TP), normalized LF (LF%), and LF/HF. No baseline HRV parameters showed any inter-group difference. The BP group had a significantly lower ΔHF and a higher ΔLF/HF than the OP group. The personality dimension, reward dependence, showed a negative correlation with ΔLF/HF and ΔLF%. BI was negatively correlated with ΔHF and positively correlated with ΔLF/HF and ΔLF%. CONCLUSIONS/SIGNIFICANCE: Borderline personality individuals show increased sympathetic activity and decreased parasympathetic activity compared to other personalities after taking methadone. The results support the hypothesis that there is an interaction between borderline personality and autonomic modulation. Public Library of Science 2012-05-22 /pmc/articles/PMC3358307/ /pubmed/22629400 http://dx.doi.org/10.1371/journal.pone.0037464 Text en Huang et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Huang, Wei-Lieh
Lin, Yu-Hsuan
Kuo, Terry B. J.
Chang, Li-Ren
Chen, Ying-Zai
Yang, Cheryl C. H.
Methadone-Mediated Autonomic Functioning of Male Patients with Heroin Dependence: The Influence of Borderline Personality Pattern
title Methadone-Mediated Autonomic Functioning of Male Patients with Heroin Dependence: The Influence of Borderline Personality Pattern
title_full Methadone-Mediated Autonomic Functioning of Male Patients with Heroin Dependence: The Influence of Borderline Personality Pattern
title_fullStr Methadone-Mediated Autonomic Functioning of Male Patients with Heroin Dependence: The Influence of Borderline Personality Pattern
title_full_unstemmed Methadone-Mediated Autonomic Functioning of Male Patients with Heroin Dependence: The Influence of Borderline Personality Pattern
title_short Methadone-Mediated Autonomic Functioning of Male Patients with Heroin Dependence: The Influence of Borderline Personality Pattern
title_sort methadone-mediated autonomic functioning of male patients with heroin dependence: the influence of borderline personality pattern
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358307/
https://www.ncbi.nlm.nih.gov/pubmed/22629400
http://dx.doi.org/10.1371/journal.pone.0037464
work_keys_str_mv AT huangweilieh methadonemediatedautonomicfunctioningofmalepatientswithheroindependencetheinfluenceofborderlinepersonalitypattern
AT linyuhsuan methadonemediatedautonomicfunctioningofmalepatientswithheroindependencetheinfluenceofborderlinepersonalitypattern
AT kuoterrybj methadonemediatedautonomicfunctioningofmalepatientswithheroindependencetheinfluenceofborderlinepersonalitypattern
AT changliren methadonemediatedautonomicfunctioningofmalepatientswithheroindependencetheinfluenceofborderlinepersonalitypattern
AT chenyingzai methadonemediatedautonomicfunctioningofmalepatientswithheroindependencetheinfluenceofborderlinepersonalitypattern
AT yangcherylch methadonemediatedautonomicfunctioningofmalepatientswithheroindependencetheinfluenceofborderlinepersonalitypattern