Deep Brain Stimulation of Nucleus Accumbens Region in Alcoholism Affects Reward Processing

The influence of bilateral deep brain stimulation (DBS) of the nucleus nucleus (NAcc) on the processing of reward in a gambling paradigm was investigated using H(2)[(15)O]-PET (positron emission tomography) in a 38-year-old man treated for severe alcohol addiction. Behavioral data analysis revealed...

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Autores principales: Heldmann, Marcus, Berding, Georg, Voges, Jürgen, Bogerts, Bernhard, Galazky, Imke, Müller, Ulf, Baillot, Gunther, Heinze, Hans-Jochen, Münte, Thomas F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358316/
https://www.ncbi.nlm.nih.gov/pubmed/22629317
http://dx.doi.org/10.1371/journal.pone.0036572
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author Heldmann, Marcus
Berding, Georg
Voges, Jürgen
Bogerts, Bernhard
Galazky, Imke
Müller, Ulf
Baillot, Gunther
Heinze, Hans-Jochen
Münte, Thomas F.
author_facet Heldmann, Marcus
Berding, Georg
Voges, Jürgen
Bogerts, Bernhard
Galazky, Imke
Müller, Ulf
Baillot, Gunther
Heinze, Hans-Jochen
Münte, Thomas F.
author_sort Heldmann, Marcus
collection PubMed
description The influence of bilateral deep brain stimulation (DBS) of the nucleus nucleus (NAcc) on the processing of reward in a gambling paradigm was investigated using H(2)[(15)O]-PET (positron emission tomography) in a 38-year-old man treated for severe alcohol addiction. Behavioral data analysis revealed a less risky, more careful choice behavior under active DBS compared to DBS switched off. PET showed win- and loss-related activations in the paracingulate cortex, temporal poles, precuneus and hippocampus under active DBS, brain areas that have been implicated in action monitoring and behavioral control. Except for the temporal pole these activations were not seen when DBS was deactivated. These findings suggest that DBS of the NAcc may act partially by improving behavioral control.
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spelling pubmed-33583162012-05-24 Deep Brain Stimulation of Nucleus Accumbens Region in Alcoholism Affects Reward Processing Heldmann, Marcus Berding, Georg Voges, Jürgen Bogerts, Bernhard Galazky, Imke Müller, Ulf Baillot, Gunther Heinze, Hans-Jochen Münte, Thomas F. PLoS One Research Article The influence of bilateral deep brain stimulation (DBS) of the nucleus nucleus (NAcc) on the processing of reward in a gambling paradigm was investigated using H(2)[(15)O]-PET (positron emission tomography) in a 38-year-old man treated for severe alcohol addiction. Behavioral data analysis revealed a less risky, more careful choice behavior under active DBS compared to DBS switched off. PET showed win- and loss-related activations in the paracingulate cortex, temporal poles, precuneus and hippocampus under active DBS, brain areas that have been implicated in action monitoring and behavioral control. Except for the temporal pole these activations were not seen when DBS was deactivated. These findings suggest that DBS of the NAcc may act partially by improving behavioral control. Public Library of Science 2012-05-22 /pmc/articles/PMC3358316/ /pubmed/22629317 http://dx.doi.org/10.1371/journal.pone.0036572 Text en Heldmann et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Heldmann, Marcus
Berding, Georg
Voges, Jürgen
Bogerts, Bernhard
Galazky, Imke
Müller, Ulf
Baillot, Gunther
Heinze, Hans-Jochen
Münte, Thomas F.
Deep Brain Stimulation of Nucleus Accumbens Region in Alcoholism Affects Reward Processing
title Deep Brain Stimulation of Nucleus Accumbens Region in Alcoholism Affects Reward Processing
title_full Deep Brain Stimulation of Nucleus Accumbens Region in Alcoholism Affects Reward Processing
title_fullStr Deep Brain Stimulation of Nucleus Accumbens Region in Alcoholism Affects Reward Processing
title_full_unstemmed Deep Brain Stimulation of Nucleus Accumbens Region in Alcoholism Affects Reward Processing
title_short Deep Brain Stimulation of Nucleus Accumbens Region in Alcoholism Affects Reward Processing
title_sort deep brain stimulation of nucleus accumbens region in alcoholism affects reward processing
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358316/
https://www.ncbi.nlm.nih.gov/pubmed/22629317
http://dx.doi.org/10.1371/journal.pone.0036572
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