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Reduction in Inter-Hemispheric Connectivity in Disorders of Consciousness

Clinical diagnosis of disorders of consciousness (DOC) caused by brain injury poses great challenges since patients are often behaviorally unresponsive. A promising new approach towards objective DOC diagnosis may be offered by the analysis of ultra-slow (<0.1 Hz) spontaneous brain activity fluct...

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Autores principales: Ovadia-Caro, Smadar, Nir, Yuval, Soddu, Andrea, Ramot, Michal, Hesselmann, Guido, Vanhaudenhuyse, Audrey, Dinstein, Ilan, Tshibanda, Jean-Flory L., Boly, Melanie, Harel, Michal, Laureys, Steven, Malach, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358327/
https://www.ncbi.nlm.nih.gov/pubmed/22629375
http://dx.doi.org/10.1371/journal.pone.0037238
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author Ovadia-Caro, Smadar
Nir, Yuval
Soddu, Andrea
Ramot, Michal
Hesselmann, Guido
Vanhaudenhuyse, Audrey
Dinstein, Ilan
Tshibanda, Jean-Flory L.
Boly, Melanie
Harel, Michal
Laureys, Steven
Malach, Rafael
author_facet Ovadia-Caro, Smadar
Nir, Yuval
Soddu, Andrea
Ramot, Michal
Hesselmann, Guido
Vanhaudenhuyse, Audrey
Dinstein, Ilan
Tshibanda, Jean-Flory L.
Boly, Melanie
Harel, Michal
Laureys, Steven
Malach, Rafael
author_sort Ovadia-Caro, Smadar
collection PubMed
description Clinical diagnosis of disorders of consciousness (DOC) caused by brain injury poses great challenges since patients are often behaviorally unresponsive. A promising new approach towards objective DOC diagnosis may be offered by the analysis of ultra-slow (<0.1 Hz) spontaneous brain activity fluctuations measured with functional magnetic resonance imaging (fMRI) during the resting-state. Previous work has shown reduced functional connectivity within the “default network”, a subset of regions known to be deactivated during engaging tasks, which correlated with the degree of consciousness impairment. However, it remains unclear whether the breakdown of connectivity is restricted to the “default network”, and to what degree changes in functional connectivity can be observed at the single subject level. Here, we analyzed resting-state inter-hemispheric connectivity in three homotopic regions of interest, which could reliably be identified based on distinct anatomical landmarks, and were part of the “Extrinsic” (externally oriented, task positive) network (pre- and postcentral gyrus, and intraparietal sulcus). Resting-state fMRI data were acquired for a group of 11 healthy subjects and 8 DOC patients. At the group level, our results indicate decreased inter-hemispheric functional connectivity in subjects with impaired awareness as compared to subjects with intact awareness. Individual connectivity scores significantly correlated with the degree of consciousness. Furthermore, a single-case statistic indicated a significant deviation from the healthy sample in 5/8 patients. Importantly, of the three patients whose connectivity indices were comparable to the healthy sample, one was diagnosed as locked-in. Taken together, our results further highlight the clinical potential of resting-state connectivity analysis and might guide the way towards a connectivity measure complementing existing DOC diagnosis.
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spelling pubmed-33583272012-05-24 Reduction in Inter-Hemispheric Connectivity in Disorders of Consciousness Ovadia-Caro, Smadar Nir, Yuval Soddu, Andrea Ramot, Michal Hesselmann, Guido Vanhaudenhuyse, Audrey Dinstein, Ilan Tshibanda, Jean-Flory L. Boly, Melanie Harel, Michal Laureys, Steven Malach, Rafael PLoS One Research Article Clinical diagnosis of disorders of consciousness (DOC) caused by brain injury poses great challenges since patients are often behaviorally unresponsive. A promising new approach towards objective DOC diagnosis may be offered by the analysis of ultra-slow (<0.1 Hz) spontaneous brain activity fluctuations measured with functional magnetic resonance imaging (fMRI) during the resting-state. Previous work has shown reduced functional connectivity within the “default network”, a subset of regions known to be deactivated during engaging tasks, which correlated with the degree of consciousness impairment. However, it remains unclear whether the breakdown of connectivity is restricted to the “default network”, and to what degree changes in functional connectivity can be observed at the single subject level. Here, we analyzed resting-state inter-hemispheric connectivity in three homotopic regions of interest, which could reliably be identified based on distinct anatomical landmarks, and were part of the “Extrinsic” (externally oriented, task positive) network (pre- and postcentral gyrus, and intraparietal sulcus). Resting-state fMRI data were acquired for a group of 11 healthy subjects and 8 DOC patients. At the group level, our results indicate decreased inter-hemispheric functional connectivity in subjects with impaired awareness as compared to subjects with intact awareness. Individual connectivity scores significantly correlated with the degree of consciousness. Furthermore, a single-case statistic indicated a significant deviation from the healthy sample in 5/8 patients. Importantly, of the three patients whose connectivity indices were comparable to the healthy sample, one was diagnosed as locked-in. Taken together, our results further highlight the clinical potential of resting-state connectivity analysis and might guide the way towards a connectivity measure complementing existing DOC diagnosis. Public Library of Science 2012-05-22 /pmc/articles/PMC3358327/ /pubmed/22629375 http://dx.doi.org/10.1371/journal.pone.0037238 Text en Ovadia-Caro et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Ovadia-Caro, Smadar
Nir, Yuval
Soddu, Andrea
Ramot, Michal
Hesselmann, Guido
Vanhaudenhuyse, Audrey
Dinstein, Ilan
Tshibanda, Jean-Flory L.
Boly, Melanie
Harel, Michal
Laureys, Steven
Malach, Rafael
Reduction in Inter-Hemispheric Connectivity in Disorders of Consciousness
title Reduction in Inter-Hemispheric Connectivity in Disorders of Consciousness
title_full Reduction in Inter-Hemispheric Connectivity in Disorders of Consciousness
title_fullStr Reduction in Inter-Hemispheric Connectivity in Disorders of Consciousness
title_full_unstemmed Reduction in Inter-Hemispheric Connectivity in Disorders of Consciousness
title_short Reduction in Inter-Hemispheric Connectivity in Disorders of Consciousness
title_sort reduction in inter-hemispheric connectivity in disorders of consciousness
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358327/
https://www.ncbi.nlm.nih.gov/pubmed/22629375
http://dx.doi.org/10.1371/journal.pone.0037238
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