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The Effect of Leflunomide on Cold and Vibratory Sensation in Patients with Rheumatoid Arthritis

OBJECTIVE: To evaluate the prevalence and risk factors of peripheral neuropathy in patients with rheumatoid arthritis (RA) treated with leflunomide (LEF) by quantitative sensory testing (QST). METHOD: A total of 94 patients were enrolledin this study, out of which 47 patients received LEF. The other...

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Autores principales: Kim, Hyung Kuk, Park, Si-Bog, Park, Jong Woo, Jang, Seong-Ho, Kim, Tae-Hwan, Sung, Yoon-Kyoung, Jun, Jae-Bum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Academy of Rehabilitation Medicine 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358676/
https://www.ncbi.nlm.nih.gov/pubmed/22639744
http://dx.doi.org/10.5535/arm.2012.36.2.207
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author Kim, Hyung Kuk
Park, Si-Bog
Park, Jong Woo
Jang, Seong-Ho
Kim, Tae-Hwan
Sung, Yoon-Kyoung
Jun, Jae-Bum
author_facet Kim, Hyung Kuk
Park, Si-Bog
Park, Jong Woo
Jang, Seong-Ho
Kim, Tae-Hwan
Sung, Yoon-Kyoung
Jun, Jae-Bum
author_sort Kim, Hyung Kuk
collection PubMed
description OBJECTIVE: To evaluate the prevalence and risk factors of peripheral neuropathy in patients with rheumatoid arthritis (RA) treated with leflunomide (LEF) by quantitative sensory testing (QST). METHOD: A total of 94 patients were enrolledin this study, out of which 47 patients received LEF. The other 47 patients received alternative disease-modifying antirheumatic drugs and served as the control group. The demographic characteristics, laboratory findings, concomitant diseases, and medication history were evaluated at the time of QST. The cooling (CDT) and vibratory detection threshold (VDT) as the representative components of QST were measured. RESULTS: Age, gender, RA duration, ESR, and CRP did not show any significant differences between the two groups. VDT did not demonstrate any significant difference in both groups. However, CDT in LEF group was significantly higher than that of the control group (8.6±2.7 in LEF vs. 5.6±3.8 in control). The proportion of RA patients in the LEF group showing abnormally high CDT was over 2 times greater than that of the control group, but these findings were not statistically significant. Age, RA duration (or LEF medication in LEF group), ESR, and CRP did not show significant correlation with CDT in both groups. VDT significantly correlated with age in both groups. CONCLUSION: LEF treatment in patients with RA may lead to abnormal CDT in QST. CDT value was not affected by age, RA duration, disease activity, or LEF duration. It remains to be determined whether QST may be a valuable non-invasive instrument to evaluate the early sensory changes in patients with RA taking LEF.
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spelling pubmed-33586762012-05-25 The Effect of Leflunomide on Cold and Vibratory Sensation in Patients with Rheumatoid Arthritis Kim, Hyung Kuk Park, Si-Bog Park, Jong Woo Jang, Seong-Ho Kim, Tae-Hwan Sung, Yoon-Kyoung Jun, Jae-Bum Ann Rehabil Med Original Article OBJECTIVE: To evaluate the prevalence and risk factors of peripheral neuropathy in patients with rheumatoid arthritis (RA) treated with leflunomide (LEF) by quantitative sensory testing (QST). METHOD: A total of 94 patients were enrolledin this study, out of which 47 patients received LEF. The other 47 patients received alternative disease-modifying antirheumatic drugs and served as the control group. The demographic characteristics, laboratory findings, concomitant diseases, and medication history were evaluated at the time of QST. The cooling (CDT) and vibratory detection threshold (VDT) as the representative components of QST were measured. RESULTS: Age, gender, RA duration, ESR, and CRP did not show any significant differences between the two groups. VDT did not demonstrate any significant difference in both groups. However, CDT in LEF group was significantly higher than that of the control group (8.6±2.7 in LEF vs. 5.6±3.8 in control). The proportion of RA patients in the LEF group showing abnormally high CDT was over 2 times greater than that of the control group, but these findings were not statistically significant. Age, RA duration (or LEF medication in LEF group), ESR, and CRP did not show significant correlation with CDT in both groups. VDT significantly correlated with age in both groups. CONCLUSION: LEF treatment in patients with RA may lead to abnormal CDT in QST. CDT value was not affected by age, RA duration, disease activity, or LEF duration. It remains to be determined whether QST may be a valuable non-invasive instrument to evaluate the early sensory changes in patients with RA taking LEF. Korean Academy of Rehabilitation Medicine 2012-04 2012-04-30 /pmc/articles/PMC3358676/ /pubmed/22639744 http://dx.doi.org/10.5535/arm.2012.36.2.207 Text en Copyright © 2012 by Korean Academy of Rehabilitation Medicine http://creativecommons.org/licenses/by-nc/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Hyung Kuk
Park, Si-Bog
Park, Jong Woo
Jang, Seong-Ho
Kim, Tae-Hwan
Sung, Yoon-Kyoung
Jun, Jae-Bum
The Effect of Leflunomide on Cold and Vibratory Sensation in Patients with Rheumatoid Arthritis
title The Effect of Leflunomide on Cold and Vibratory Sensation in Patients with Rheumatoid Arthritis
title_full The Effect of Leflunomide on Cold and Vibratory Sensation in Patients with Rheumatoid Arthritis
title_fullStr The Effect of Leflunomide on Cold and Vibratory Sensation in Patients with Rheumatoid Arthritis
title_full_unstemmed The Effect of Leflunomide on Cold and Vibratory Sensation in Patients with Rheumatoid Arthritis
title_short The Effect of Leflunomide on Cold and Vibratory Sensation in Patients with Rheumatoid Arthritis
title_sort effect of leflunomide on cold and vibratory sensation in patients with rheumatoid arthritis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358676/
https://www.ncbi.nlm.nih.gov/pubmed/22639744
http://dx.doi.org/10.5535/arm.2012.36.2.207
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