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Visualisation of variable binding pockets on protein surfaces by probabilistic analysis of related structure sets

BACKGROUND: Protein structures provide a valuable resource for rational drug design. For a protein with no known ligand, computational tools can predict surface pockets that are of suitable size and shape to accommodate a complementary small-molecule drug. However, pocket prediction against single s...

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Detalles Bibliográficos
Autores principales:	Ashford, Paul, Moss, David S, Alex, Alexander, Yeap, Siew K, Povia, Alice, Nobeli, Irene, Williams, Mark A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Methodology Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359218/ https://www.ncbi.nlm.nih.gov/pubmed/22417279 http://dx.doi.org/10.1186/1471-2105-13-39

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