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Fluorescence anisotropy of diphenylhexatriene and its cationic Trimethylamino derivative in liquid dipalmitoylphosphatidylcholine liposomes: opposing responses to isoflurane

BACKGROUND: The mechanism of action of volatile general anesthetics has not yet been resolved. In order to identify the effects of isoflurane on the membrane, we measured the steady-state anisotropy of two fluorescent probes that reside at different depths. Incorporation of anesthetic was confirmed...

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Detalles Bibliográficos
Autores principales: Nelson, Steven C, Neeley, Steven K, Melonakos, Eric D, Bell, John D, Busath, David D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359235/
https://www.ncbi.nlm.nih.gov/pubmed/22444827
http://dx.doi.org/10.1186/2046-1682-5-5