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Medium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) γ Activators and Pan-PPAR Partial Agonists

Thiazolidinediones (TZDs) act through peroxisome proliferator activated receptor (PPAR) γ to increase insulin sensitivity in type 2 diabetes (T2DM), but deleterious effects of these ligands mean that selective modulators with improved clinical profiles are needed. We obtained a crystal structure of...

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Detalles Bibliográficos
Autores principales:	Liberato, Marcelo Vizoná, Nascimento, Alessandro S., Ayers, Steven D., Lin, Jean Z., Cvoro, Aleksandra, Silveira, Rodrigo L., Martínez, Leandro, Souza, Paulo C. T., Saidemberg, Daniel, Deng, Tuo, Amato, Angela Angelica, Togashi, Marie, Hsueh, Willa A., Phillips, Kevin, Palma, Mário Sérgio, Neves, Francisco A. R., Skaf, Munir S., Webb, Paul, Polikarpov, Igor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359336/ https://www.ncbi.nlm.nih.gov/pubmed/22649490 http://dx.doi.org/10.1371/journal.pone.0036297

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