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Kinetic studies of novel inhibitors of endomorphin degrading enzymes

Endomorphins (EMs), two endogenous μ-opioid receptor selective ligands, are attractive lead compounds for opioid-based pain management studies. However, these peptides are quickly degraded by peptidases, in particular by dipeptidylpeptidase IV (DPP IV) and aminopeptidase M (APM). Targeting enzymatic...

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Detalles Bibliográficos
Autores principales:	Perlikowska, Renata, Fichna, Jakub, do-Rego, Jean Claude, Gach, Katarzyna, Janecka, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2011
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359464/ https://www.ncbi.nlm.nih.gov/pubmed/22707871 http://dx.doi.org/10.1007/s00044-011-9666-5

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