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Locally Advanced Cancer of the Esophagus, Current Treatment Strategies, and Future Directions
For patients with locally advanced esophageal cancer no clear standard of care exists. Notwithstanding several negative phase III studies the data provide support for so-called trimodality treatment and this is probably the most common approach. Even the role of surgery has been questioned. These al...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Research Foundation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359480/ https://www.ncbi.nlm.nih.gov/pubmed/22655277 http://dx.doi.org/10.3389/fonc.2012.00052 |
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author | Rahma, Osama E. Greten, Tim F. Duffy, Austin |
author_facet | Rahma, Osama E. Greten, Tim F. Duffy, Austin |
author_sort | Rahma, Osama E. |
collection | PubMed |
description | For patients with locally advanced esophageal cancer no clear standard of care exists. Notwithstanding several negative phase III studies the data provide support for so-called trimodality treatment and this is probably the most common approach. Even the role of surgery has been questioned. These alternative approaches are set against a changing epidemiological background whereby adenocarcinoma has become the predominant tumor type, at least in the western world. In recent times an emphasis has been placed on the better selection of patients, predominantly based on data that shows a markedly improved survival in those who exhibit a response to neo-adjuvant therapy. In this article we review the major studies and discuss new approaches to the management of patients with locally advanced cancer of the esophagus. |
format | Online Article Text |
id | pubmed-3359480 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33594802012-05-31 Locally Advanced Cancer of the Esophagus, Current Treatment Strategies, and Future Directions Rahma, Osama E. Greten, Tim F. Duffy, Austin Front Oncol Oncology For patients with locally advanced esophageal cancer no clear standard of care exists. Notwithstanding several negative phase III studies the data provide support for so-called trimodality treatment and this is probably the most common approach. Even the role of surgery has been questioned. These alternative approaches are set against a changing epidemiological background whereby adenocarcinoma has become the predominant tumor type, at least in the western world. In recent times an emphasis has been placed on the better selection of patients, predominantly based on data that shows a markedly improved survival in those who exhibit a response to neo-adjuvant therapy. In this article we review the major studies and discuss new approaches to the management of patients with locally advanced cancer of the esophagus. Frontiers Research Foundation 2012-05-24 /pmc/articles/PMC3359480/ /pubmed/22655277 http://dx.doi.org/10.3389/fonc.2012.00052 Text en Copyright © 2012 Rahma, Greten and Duffy. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited. |
spellingShingle | Oncology Rahma, Osama E. Greten, Tim F. Duffy, Austin Locally Advanced Cancer of the Esophagus, Current Treatment Strategies, and Future Directions |
title | Locally Advanced Cancer of the Esophagus, Current Treatment Strategies, and Future Directions |
title_full | Locally Advanced Cancer of the Esophagus, Current Treatment Strategies, and Future Directions |
title_fullStr | Locally Advanced Cancer of the Esophagus, Current Treatment Strategies, and Future Directions |
title_full_unstemmed | Locally Advanced Cancer of the Esophagus, Current Treatment Strategies, and Future Directions |
title_short | Locally Advanced Cancer of the Esophagus, Current Treatment Strategies, and Future Directions |
title_sort | locally advanced cancer of the esophagus, current treatment strategies, and future directions |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359480/ https://www.ncbi.nlm.nih.gov/pubmed/22655277 http://dx.doi.org/10.3389/fonc.2012.00052 |
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