The Metabolism of Baicalin in Rat and the Biological Activities of the Metabolites

Baicalin is one of the major bioactive constituents of Scutellariae Radix, but the biotransformation of it is poorly understood. In this paper, the metabolism of baicalin in rat was studied. Nine metabolites including one new compound were isolated and identified structurally. The plausible scheme f...

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Detalles Bibliográficos
Autores principales: Wang, Yi, Yang, Jingyu, Li, Xian, Wang, Jinhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359663/
https://www.ncbi.nlm.nih.gov/pubmed/22654953
http://dx.doi.org/10.1155/2012/404529
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author Wang, Yi
Yang, Jingyu
Li, Xian
Wang, Jinhui
author_facet Wang, Yi
Yang, Jingyu
Li, Xian
Wang, Jinhui
author_sort Wang, Yi
collection PubMed
description Baicalin is one of the major bioactive constituents of Scutellariae Radix, but the biotransformation of it is poorly understood. In this paper, the metabolism of baicalin in rat was studied. Nine metabolites including one new compound were isolated and identified structurally. The plausible scheme for the biotransformation pathways of baicalin in the rats was deduced. And the main metabolites were evaluated for their antioxidation and anti-inflammation biological activities for the first time.
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spelling pubmed-33596632012-05-31 The Metabolism of Baicalin in Rat and the Biological Activities of the Metabolites Wang, Yi Yang, Jingyu Li, Xian Wang, Jinhui Evid Based Complement Alternat Med Research Article Baicalin is one of the major bioactive constituents of Scutellariae Radix, but the biotransformation of it is poorly understood. In this paper, the metabolism of baicalin in rat was studied. Nine metabolites including one new compound were isolated and identified structurally. The plausible scheme for the biotransformation pathways of baicalin in the rats was deduced. And the main metabolites were evaluated for their antioxidation and anti-inflammation biological activities for the first time. Hindawi Publishing Corporation 2012 2012-05-13 /pmc/articles/PMC3359663/ /pubmed/22654953 http://dx.doi.org/10.1155/2012/404529 Text en Copyright © 2012 Yi Wang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Yi
Yang, Jingyu
Li, Xian
Wang, Jinhui
The Metabolism of Baicalin in Rat and the Biological Activities of the Metabolites
title The Metabolism of Baicalin in Rat and the Biological Activities of the Metabolites
title_full The Metabolism of Baicalin in Rat and the Biological Activities of the Metabolites
title_fullStr The Metabolism of Baicalin in Rat and the Biological Activities of the Metabolites
title_full_unstemmed The Metabolism of Baicalin in Rat and the Biological Activities of the Metabolites
title_short The Metabolism of Baicalin in Rat and the Biological Activities of the Metabolites
title_sort metabolism of baicalin in rat and the biological activities of the metabolites
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359663/
https://www.ncbi.nlm.nih.gov/pubmed/22654953
http://dx.doi.org/10.1155/2012/404529
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