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Heparin Increases HLA-G Levels in Primary Antiphospholipid Syndrome
Objectives. The aim of this study was to investigate the HLA-G serum levels in Primary Antiphospholipid Syndrome (PAPS) patients, its impact on clinical and laboratory findings, and heparin treatment. Methods. Forty-four PAPS patients were age and gender matched with 43 controls. HLA-G serum levels...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359668/ https://www.ncbi.nlm.nih.gov/pubmed/22654952 http://dx.doi.org/10.1155/2012/232390 |
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author | de Carvalho, Jozélio Freire de Oliveira, Ricardo M. Rodrigues, Carlos Ewerton Maia Glezer, Andréa Bonfá, Eloísa Pereira, Rosa Maria Rodrigues |
author_facet | de Carvalho, Jozélio Freire de Oliveira, Ricardo M. Rodrigues, Carlos Ewerton Maia Glezer, Andréa Bonfá, Eloísa Pereira, Rosa Maria Rodrigues |
author_sort | de Carvalho, Jozélio Freire |
collection | PubMed |
description | Objectives. The aim of this study was to investigate the HLA-G serum levels in Primary Antiphospholipid Syndrome (PAPS) patients, its impact on clinical and laboratory findings, and heparin treatment. Methods. Forty-four PAPS patients were age and gender matched with 43 controls. HLA-G serum levels were measured using an enzyme-linked immunosorbent assay (ELISA). Results. An increase in soluble HLA-G levels was found in patients compared to controls (3.35 (0–22.9) versus 1.1 (0–14), P = 0.017). There were no significant differences in HLA-G levels between patients with and without obstetric events, arterial thrombosis, venous thrombosis, or stroke. Sixty-six percent of patients were being treated with heparin. Interestingly, patients treated with heparin had higher HLA-G levels than ones who were not treated with this medication (5 (0–22.9) versus 1.8 (0–16) ng/mL, P = 0.038). Furthermore, patients on heparin who experienced obstetric events had a trend to increased HLA-G levels compared to patients who were not on heparin and did not have obstetric events (5.8 (0–22.9) versus 2 (0–15.2) ng/mL, P = 0.05). Conclusion. This is the first study to demonstrate that serum HLA-G levels are increased in APS patients. We also demonstrated that heparin increases HLA-G levels and may increase tolerance towards autoantigens. |
format | Online Article Text |
id | pubmed-3359668 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33596682012-05-31 Heparin Increases HLA-G Levels in Primary Antiphospholipid Syndrome de Carvalho, Jozélio Freire de Oliveira, Ricardo M. Rodrigues, Carlos Ewerton Maia Glezer, Andréa Bonfá, Eloísa Pereira, Rosa Maria Rodrigues Clin Dev Immunol Clinical Study Objectives. The aim of this study was to investigate the HLA-G serum levels in Primary Antiphospholipid Syndrome (PAPS) patients, its impact on clinical and laboratory findings, and heparin treatment. Methods. Forty-four PAPS patients were age and gender matched with 43 controls. HLA-G serum levels were measured using an enzyme-linked immunosorbent assay (ELISA). Results. An increase in soluble HLA-G levels was found in patients compared to controls (3.35 (0–22.9) versus 1.1 (0–14), P = 0.017). There were no significant differences in HLA-G levels between patients with and without obstetric events, arterial thrombosis, venous thrombosis, or stroke. Sixty-six percent of patients were being treated with heparin. Interestingly, patients treated with heparin had higher HLA-G levels than ones who were not treated with this medication (5 (0–22.9) versus 1.8 (0–16) ng/mL, P = 0.038). Furthermore, patients on heparin who experienced obstetric events had a trend to increased HLA-G levels compared to patients who were not on heparin and did not have obstetric events (5.8 (0–22.9) versus 2 (0–15.2) ng/mL, P = 0.05). Conclusion. This is the first study to demonstrate that serum HLA-G levels are increased in APS patients. We also demonstrated that heparin increases HLA-G levels and may increase tolerance towards autoantigens. Hindawi Publishing Corporation 2012 2012-05-13 /pmc/articles/PMC3359668/ /pubmed/22654952 http://dx.doi.org/10.1155/2012/232390 Text en Copyright © 2012 Jozélio Freire de Carvalho et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study de Carvalho, Jozélio Freire de Oliveira, Ricardo M. Rodrigues, Carlos Ewerton Maia Glezer, Andréa Bonfá, Eloísa Pereira, Rosa Maria Rodrigues Heparin Increases HLA-G Levels in Primary Antiphospholipid Syndrome |
title | Heparin Increases HLA-G Levels in Primary Antiphospholipid Syndrome |
title_full | Heparin Increases HLA-G Levels in Primary Antiphospholipid Syndrome |
title_fullStr | Heparin Increases HLA-G Levels in Primary Antiphospholipid Syndrome |
title_full_unstemmed | Heparin Increases HLA-G Levels in Primary Antiphospholipid Syndrome |
title_short | Heparin Increases HLA-G Levels in Primary Antiphospholipid Syndrome |
title_sort | heparin increases hla-g levels in primary antiphospholipid syndrome |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359668/ https://www.ncbi.nlm.nih.gov/pubmed/22654952 http://dx.doi.org/10.1155/2012/232390 |
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