Cargando…

Heparin Increases HLA-G Levels in Primary Antiphospholipid Syndrome

Objectives. The aim of this study was to investigate the HLA-G serum levels in Primary Antiphospholipid Syndrome (PAPS) patients, its impact on clinical and laboratory findings, and heparin treatment. Methods. Forty-four PAPS patients were age and gender matched with 43 controls. HLA-G serum levels...

Descripción completa

Detalles Bibliográficos
Autores principales: de Carvalho, Jozélio Freire, de Oliveira, Ricardo M., Rodrigues, Carlos Ewerton Maia, Glezer, Andréa, Bonfá, Eloísa, Pereira, Rosa Maria Rodrigues
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359668/
https://www.ncbi.nlm.nih.gov/pubmed/22654952
http://dx.doi.org/10.1155/2012/232390
_version_ 1782233894929563648
author de Carvalho, Jozélio Freire
de Oliveira, Ricardo M.
Rodrigues, Carlos Ewerton Maia
Glezer, Andréa
Bonfá, Eloísa
Pereira, Rosa Maria Rodrigues
author_facet de Carvalho, Jozélio Freire
de Oliveira, Ricardo M.
Rodrigues, Carlos Ewerton Maia
Glezer, Andréa
Bonfá, Eloísa
Pereira, Rosa Maria Rodrigues
author_sort de Carvalho, Jozélio Freire
collection PubMed
description Objectives. The aim of this study was to investigate the HLA-G serum levels in Primary Antiphospholipid Syndrome (PAPS) patients, its impact on clinical and laboratory findings, and heparin treatment. Methods. Forty-four PAPS patients were age and gender matched with 43 controls. HLA-G serum levels were measured using an enzyme-linked immunosorbent assay (ELISA). Results. An increase in soluble HLA-G levels was found in patients compared to controls (3.35 (0–22.9) versus 1.1 (0–14), P = 0.017). There were no significant differences in HLA-G levels between patients with and without obstetric events, arterial thrombosis, venous thrombosis, or stroke. Sixty-six percent of patients were being treated with heparin. Interestingly, patients treated with heparin had higher HLA-G levels than ones who were not treated with this medication (5 (0–22.9) versus 1.8 (0–16) ng/mL, P = 0.038). Furthermore, patients on heparin who experienced obstetric events had a trend to increased HLA-G levels compared to patients who were not on heparin and did not have obstetric events (5.8 (0–22.9) versus 2 (0–15.2) ng/mL, P = 0.05). Conclusion. This is the first study to demonstrate that serum HLA-G levels are increased in APS patients. We also demonstrated that heparin increases HLA-G levels and may increase tolerance towards autoantigens.
format Online
Article
Text
id pubmed-3359668
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-33596682012-05-31 Heparin Increases HLA-G Levels in Primary Antiphospholipid Syndrome de Carvalho, Jozélio Freire de Oliveira, Ricardo M. Rodrigues, Carlos Ewerton Maia Glezer, Andréa Bonfá, Eloísa Pereira, Rosa Maria Rodrigues Clin Dev Immunol Clinical Study Objectives. The aim of this study was to investigate the HLA-G serum levels in Primary Antiphospholipid Syndrome (PAPS) patients, its impact on clinical and laboratory findings, and heparin treatment. Methods. Forty-four PAPS patients were age and gender matched with 43 controls. HLA-G serum levels were measured using an enzyme-linked immunosorbent assay (ELISA). Results. An increase in soluble HLA-G levels was found in patients compared to controls (3.35 (0–22.9) versus 1.1 (0–14), P = 0.017). There were no significant differences in HLA-G levels between patients with and without obstetric events, arterial thrombosis, venous thrombosis, or stroke. Sixty-six percent of patients were being treated with heparin. Interestingly, patients treated with heparin had higher HLA-G levels than ones who were not treated with this medication (5 (0–22.9) versus 1.8 (0–16) ng/mL, P = 0.038). Furthermore, patients on heparin who experienced obstetric events had a trend to increased HLA-G levels compared to patients who were not on heparin and did not have obstetric events (5.8 (0–22.9) versus 2 (0–15.2) ng/mL, P = 0.05). Conclusion. This is the first study to demonstrate that serum HLA-G levels are increased in APS patients. We also demonstrated that heparin increases HLA-G levels and may increase tolerance towards autoantigens. Hindawi Publishing Corporation 2012 2012-05-13 /pmc/articles/PMC3359668/ /pubmed/22654952 http://dx.doi.org/10.1155/2012/232390 Text en Copyright © 2012 Jozélio Freire de Carvalho et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
de Carvalho, Jozélio Freire
de Oliveira, Ricardo M.
Rodrigues, Carlos Ewerton Maia
Glezer, Andréa
Bonfá, Eloísa
Pereira, Rosa Maria Rodrigues
Heparin Increases HLA-G Levels in Primary Antiphospholipid Syndrome
title Heparin Increases HLA-G Levels in Primary Antiphospholipid Syndrome
title_full Heparin Increases HLA-G Levels in Primary Antiphospholipid Syndrome
title_fullStr Heparin Increases HLA-G Levels in Primary Antiphospholipid Syndrome
title_full_unstemmed Heparin Increases HLA-G Levels in Primary Antiphospholipid Syndrome
title_short Heparin Increases HLA-G Levels in Primary Antiphospholipid Syndrome
title_sort heparin increases hla-g levels in primary antiphospholipid syndrome
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359668/
https://www.ncbi.nlm.nih.gov/pubmed/22654952
http://dx.doi.org/10.1155/2012/232390
work_keys_str_mv AT decarvalhojozeliofreire heparinincreaseshlaglevelsinprimaryantiphospholipidsyndrome
AT deoliveiraricardom heparinincreaseshlaglevelsinprimaryantiphospholipidsyndrome
AT rodriguescarlosewertonmaia heparinincreaseshlaglevelsinprimaryantiphospholipidsyndrome
AT glezerandrea heparinincreaseshlaglevelsinprimaryantiphospholipidsyndrome
AT bonfaeloisa heparinincreaseshlaglevelsinprimaryantiphospholipidsyndrome
AT pereirarosamariarodrigues heparinincreaseshlaglevelsinprimaryantiphospholipidsyndrome