NMDA Receptors of Gastric-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus Mediate the Regulation of Gastric Emptying by EA at Weishu (BL21)

A large number of studies have been conducted to explore the efficacy of electroacupuncture (EA) for the treatment of gastrointestinal motility. While several lines of evidence addressed the basic mechanism of EA on gastrointestinal motility regarding effects of limb and abdomen points, the mechanis...

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Detalles Bibliográficos
Autores principales: Zhang, Xin, Cheng, Bin, Jing, Xianghong, Qiao, Yongfa, Gao, Xinyan, Yu, Huijuan, Zhu, Bing, Qiao, Haifa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359673/
https://www.ncbi.nlm.nih.gov/pubmed/22654955
http://dx.doi.org/10.1155/2012/583479
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author Zhang, Xin
Cheng, Bin
Jing, Xianghong
Qiao, Yongfa
Gao, Xinyan
Yu, Huijuan
Zhu, Bing
Qiao, Haifa
author_facet Zhang, Xin
Cheng, Bin
Jing, Xianghong
Qiao, Yongfa
Gao, Xinyan
Yu, Huijuan
Zhu, Bing
Qiao, Haifa
author_sort Zhang, Xin
collection PubMed
description A large number of studies have been conducted to explore the efficacy of electroacupuncture (EA) for the treatment of gastrointestinal motility. While several lines of evidence addressed the basic mechanism of EA on gastrointestinal motility regarding effects of limb and abdomen points, the mechanism for effects of the back points on gastric motility still remains unclear. Here we report that the NMDA receptor (NMDAR) antagonist kynurenic acid inhibited the gastric emptying increase induced by high-intensity EA at BL21 and agonist NMDA enhanced the effect of the same treatment. EA at BL21 enhanced NMDAR, but not AMPA receptor (AMPAR) component of miniature excitatory postsynaptic current (mEPSC) in gastric-projecting neurons of the dorsal motor nucleus of the vagus (DMV). In sum, our data demonstrate an important role of NMDAR-mediated synaptic transmission of gastric-projecting DMV neurons in mediating EA at BL21-induced enhancement of gastric emptying.
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spelling pubmed-33596732012-05-31 NMDA Receptors of Gastric-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus Mediate the Regulation of Gastric Emptying by EA at Weishu (BL21) Zhang, Xin Cheng, Bin Jing, Xianghong Qiao, Yongfa Gao, Xinyan Yu, Huijuan Zhu, Bing Qiao, Haifa Evid Based Complement Alternat Med Research Article A large number of studies have been conducted to explore the efficacy of electroacupuncture (EA) for the treatment of gastrointestinal motility. While several lines of evidence addressed the basic mechanism of EA on gastrointestinal motility regarding effects of limb and abdomen points, the mechanism for effects of the back points on gastric motility still remains unclear. Here we report that the NMDA receptor (NMDAR) antagonist kynurenic acid inhibited the gastric emptying increase induced by high-intensity EA at BL21 and agonist NMDA enhanced the effect of the same treatment. EA at BL21 enhanced NMDAR, but not AMPA receptor (AMPAR) component of miniature excitatory postsynaptic current (mEPSC) in gastric-projecting neurons of the dorsal motor nucleus of the vagus (DMV). In sum, our data demonstrate an important role of NMDAR-mediated synaptic transmission of gastric-projecting DMV neurons in mediating EA at BL21-induced enhancement of gastric emptying. Hindawi Publishing Corporation 2012 2012-05-13 /pmc/articles/PMC3359673/ /pubmed/22654955 http://dx.doi.org/10.1155/2012/583479 Text en Copyright © 2012 Xin Zhang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Xin
Cheng, Bin
Jing, Xianghong
Qiao, Yongfa
Gao, Xinyan
Yu, Huijuan
Zhu, Bing
Qiao, Haifa
NMDA Receptors of Gastric-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus Mediate the Regulation of Gastric Emptying by EA at Weishu (BL21)
title NMDA Receptors of Gastric-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus Mediate the Regulation of Gastric Emptying by EA at Weishu (BL21)
title_full NMDA Receptors of Gastric-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus Mediate the Regulation of Gastric Emptying by EA at Weishu (BL21)
title_fullStr NMDA Receptors of Gastric-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus Mediate the Regulation of Gastric Emptying by EA at Weishu (BL21)
title_full_unstemmed NMDA Receptors of Gastric-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus Mediate the Regulation of Gastric Emptying by EA at Weishu (BL21)
title_short NMDA Receptors of Gastric-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus Mediate the Regulation of Gastric Emptying by EA at Weishu (BL21)
title_sort nmda receptors of gastric-projecting neurons in the dorsal motor nucleus of the vagus mediate the regulation of gastric emptying by ea at weishu (bl21)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359673/
https://www.ncbi.nlm.nih.gov/pubmed/22654955
http://dx.doi.org/10.1155/2012/583479
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