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Reversible Masking Using Low-Molecular-Weight Neutral Lipids to Achieve Optimal-Targeted Delivery
Intravenous injection of therapeutics is required to effectively treat or cure metastatic cancer, certain cardiovascular diseases, and other acquired or inherited diseases. Using this route of delivery allows potential uptake in all disease targets that are accessed by the bloodstream. However, norm...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359711/ https://www.ncbi.nlm.nih.gov/pubmed/22655199 http://dx.doi.org/10.1155/2012/173465 |
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author | Templeton, Nancy Smyth Senzer, Neil |
author_facet | Templeton, Nancy Smyth Senzer, Neil |
author_sort | Templeton, Nancy Smyth |
collection | PubMed |
description | Intravenous injection of therapeutics is required to effectively treat or cure metastatic cancer, certain cardiovascular diseases, and other acquired or inherited diseases. Using this route of delivery allows potential uptake in all disease targets that are accessed by the bloodstream. However, normal tissues and organs also have the potential for uptake of therapeutic agents. Therefore, investigators have used targeted delivery to attempt delivery solely to the target cells; however, use of ligands on the surface of delivery vehicles to target specific cell surface receptors is not sufficient to avoid nonspecific uptake. PEGylation has been used for decades to try to avoid nonspecific uptake but suffers from many problems known as “The PEGylation Dilemma.” We have solved this dilemma by replacing PEGylation with reversible masking using low-molecular-weight neutral lipids in order to achieve optimal-targeted delivery solely to target cells. Our paper will focus on this topic. |
format | Online Article Text |
id | pubmed-3359711 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33597112012-05-31 Reversible Masking Using Low-Molecular-Weight Neutral Lipids to Achieve Optimal-Targeted Delivery Templeton, Nancy Smyth Senzer, Neil J Drug Deliv Review Article Intravenous injection of therapeutics is required to effectively treat or cure metastatic cancer, certain cardiovascular diseases, and other acquired or inherited diseases. Using this route of delivery allows potential uptake in all disease targets that are accessed by the bloodstream. However, normal tissues and organs also have the potential for uptake of therapeutic agents. Therefore, investigators have used targeted delivery to attempt delivery solely to the target cells; however, use of ligands on the surface of delivery vehicles to target specific cell surface receptors is not sufficient to avoid nonspecific uptake. PEGylation has been used for decades to try to avoid nonspecific uptake but suffers from many problems known as “The PEGylation Dilemma.” We have solved this dilemma by replacing PEGylation with reversible masking using low-molecular-weight neutral lipids in order to achieve optimal-targeted delivery solely to target cells. Our paper will focus on this topic. Hindawi Publishing Corporation 2012 2012-05-10 /pmc/articles/PMC3359711/ /pubmed/22655199 http://dx.doi.org/10.1155/2012/173465 Text en Copyright © 2012 N. S. Templeton and N. Senzer. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Templeton, Nancy Smyth Senzer, Neil Reversible Masking Using Low-Molecular-Weight Neutral Lipids to Achieve Optimal-Targeted Delivery |
title | Reversible Masking Using Low-Molecular-Weight Neutral Lipids to Achieve Optimal-Targeted Delivery |
title_full | Reversible Masking Using Low-Molecular-Weight Neutral Lipids to Achieve Optimal-Targeted Delivery |
title_fullStr | Reversible Masking Using Low-Molecular-Weight Neutral Lipids to Achieve Optimal-Targeted Delivery |
title_full_unstemmed | Reversible Masking Using Low-Molecular-Weight Neutral Lipids to Achieve Optimal-Targeted Delivery |
title_short | Reversible Masking Using Low-Molecular-Weight Neutral Lipids to Achieve Optimal-Targeted Delivery |
title_sort | reversible masking using low-molecular-weight neutral lipids to achieve optimal-targeted delivery |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359711/ https://www.ncbi.nlm.nih.gov/pubmed/22655199 http://dx.doi.org/10.1155/2012/173465 |
work_keys_str_mv | AT templetonnancysmyth reversiblemaskingusinglowmolecularweightneutrallipidstoachieveoptimaltargeteddelivery AT senzerneil reversiblemaskingusinglowmolecularweightneutrallipidstoachieveoptimaltargeteddelivery |