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Schisandrin B as a Hormetic Agent for Preventing Age-Related Neurodegenerative Diseases

Oxidative stress and mitochondrial dysfunction have been implicated in the pathogenesis of neurodegenerative diseases, with the latter preceding the appearance of clinical symptoms. The energy failure resulting from mitochondrial dysfunction further impedes brain function, which demands large amount...

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Detalles Bibliográficos
Autores principales: Lam, Philip Y., Ko, Kam Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359732/
https://www.ncbi.nlm.nih.gov/pubmed/22666518
http://dx.doi.org/10.1155/2012/250825
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author Lam, Philip Y.
Ko, Kam Ming
author_facet Lam, Philip Y.
Ko, Kam Ming
author_sort Lam, Philip Y.
collection PubMed
description Oxidative stress and mitochondrial dysfunction have been implicated in the pathogenesis of neurodegenerative diseases, with the latter preceding the appearance of clinical symptoms. The energy failure resulting from mitochondrial dysfunction further impedes brain function, which demands large amounts of energy. Schisandrin B (Sch B), an active ingredient isolated from Fructus Schisandrae, has been shown to afford generalized tissue protection against oxidative damage in various organs, including the brain, of experimental animals. Recent experimental findings have further demonstrated that Sch B can protect neuronal cells against oxidative challenge, presumably by functioning as a hormetic agent to sustain cellular redox homeostasis and mitoenergetic capacity in neuronal cells. The combined actions of Sch B offer a promising prospect for preventing or possibly delaying the onset of neurodegenerative diseases, as well as enhancing brain health.
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spelling pubmed-33597322012-06-04 Schisandrin B as a Hormetic Agent for Preventing Age-Related Neurodegenerative Diseases Lam, Philip Y. Ko, Kam Ming Oxid Med Cell Longev Review Article Oxidative stress and mitochondrial dysfunction have been implicated in the pathogenesis of neurodegenerative diseases, with the latter preceding the appearance of clinical symptoms. The energy failure resulting from mitochondrial dysfunction further impedes brain function, which demands large amounts of energy. Schisandrin B (Sch B), an active ingredient isolated from Fructus Schisandrae, has been shown to afford generalized tissue protection against oxidative damage in various organs, including the brain, of experimental animals. Recent experimental findings have further demonstrated that Sch B can protect neuronal cells against oxidative challenge, presumably by functioning as a hormetic agent to sustain cellular redox homeostasis and mitoenergetic capacity in neuronal cells. The combined actions of Sch B offer a promising prospect for preventing or possibly delaying the onset of neurodegenerative diseases, as well as enhancing brain health. Hindawi Publishing Corporation 2012 2012-05-13 /pmc/articles/PMC3359732/ /pubmed/22666518 http://dx.doi.org/10.1155/2012/250825 Text en Copyright © 2012 P. Y. Lam and K. M. Ko. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lam, Philip Y.
Ko, Kam Ming
Schisandrin B as a Hormetic Agent for Preventing Age-Related Neurodegenerative Diseases
title Schisandrin B as a Hormetic Agent for Preventing Age-Related Neurodegenerative Diseases
title_full Schisandrin B as a Hormetic Agent for Preventing Age-Related Neurodegenerative Diseases
title_fullStr Schisandrin B as a Hormetic Agent for Preventing Age-Related Neurodegenerative Diseases
title_full_unstemmed Schisandrin B as a Hormetic Agent for Preventing Age-Related Neurodegenerative Diseases
title_short Schisandrin B as a Hormetic Agent for Preventing Age-Related Neurodegenerative Diseases
title_sort schisandrin b as a hormetic agent for preventing age-related neurodegenerative diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359732/
https://www.ncbi.nlm.nih.gov/pubmed/22666518
http://dx.doi.org/10.1155/2012/250825
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