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Regulation of p53: a collaboration between Mdm2 and MdmX

p53 plays an important role in the regulation of the cell cycle, DNA repair, and apoptosis and is an attractive cancer therapeutic target. Mdm2 and Mdmx are recognized as the main p53 negative regulators. Although it is still unknown why Mdm2 and Mdmx both are required for p53 degradation, a model h...

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Detalles Bibliográficos
Autores principales:	Pei, Dongsheng, Zhang, Yanping, Zheng, Junnian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2012
Materias:	Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359881/ https://www.ncbi.nlm.nih.gov/pubmed/22410433

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