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Estimating the Fitness Cost of Escape from HLA Presentation in HIV-1 Protease and Reverse Transcriptase

Human immunodeficiency virus (HIV-1) is, like most pathogens, under selective pressure to escape the immune system of its host. In particular, HIV-1 can avoid recognition by cytotoxic T lymphocytes (CTLs) by altering the binding affinity of viral peptides to human leukocyte antigen (HLA) molecules,...

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Detalles Bibliográficos
Autores principales:	Mostowy, Rafal, Kouyos, Roger D., Hoof, Ilka, Hinkley, Trevor, Haddad, Mojgan, Whitcomb, Jeannette M., Petropoulos, Christos J., Keşmir, Can, Bonhoeffer, Sebastian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359966/ https://www.ncbi.nlm.nih.gov/pubmed/22654656 http://dx.doi.org/10.1371/journal.pcbi.1002525

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