Cargando…

abd-A Regulation by the iab-8 Noncoding RNA

The homeotic genes in Drosophila melanogaster are aligned on the chromosome in the order of the body segments that they affect. The genes affecting the more posterior segments repress the more anterior genes. This posterior dominance rule must be qualified in the case of abdominal-A (abd-A) repressi...

Descripción completa

Detalles Bibliográficos
Autores principales: Gummalla, Maheshwar, Maeda, Robert K., Castro Alvarez, Javier J., Gyurkovics, Henrik, Singari, Swetha, Edwards, Kevin A., Karch, François, Bender, Welcome
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359974/
https://www.ncbi.nlm.nih.gov/pubmed/22654672
http://dx.doi.org/10.1371/journal.pgen.1002720
_version_ 1782233929204367360
author Gummalla, Maheshwar
Maeda, Robert K.
Castro Alvarez, Javier J.
Gyurkovics, Henrik
Singari, Swetha
Edwards, Kevin A.
Karch, François
Bender, Welcome
author_facet Gummalla, Maheshwar
Maeda, Robert K.
Castro Alvarez, Javier J.
Gyurkovics, Henrik
Singari, Swetha
Edwards, Kevin A.
Karch, François
Bender, Welcome
author_sort Gummalla, Maheshwar
collection PubMed
description The homeotic genes in Drosophila melanogaster are aligned on the chromosome in the order of the body segments that they affect. The genes affecting the more posterior segments repress the more anterior genes. This posterior dominance rule must be qualified in the case of abdominal-A (abd-A) repression by Abdominal-B (Abd-B). Animals lacking Abd-B show ectopic expression of abd-A in the epidermis of the eighth abdominal segment, but not in the central nervous system. Repression in these neuronal cells is accomplished by a 92 kb noncoding RNA. This “iab-8 RNA” produces a micro RNA to repress abd-A, but also has a second, redundant repression mechanism that acts only “in cis.” Transcriptional interference with the abd-A promoter is the most likely mechanism.
format Online
Article
Text
id pubmed-3359974
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-33599742012-05-31 abd-A Regulation by the iab-8 Noncoding RNA Gummalla, Maheshwar Maeda, Robert K. Castro Alvarez, Javier J. Gyurkovics, Henrik Singari, Swetha Edwards, Kevin A. Karch, François Bender, Welcome PLoS Genet Research Article The homeotic genes in Drosophila melanogaster are aligned on the chromosome in the order of the body segments that they affect. The genes affecting the more posterior segments repress the more anterior genes. This posterior dominance rule must be qualified in the case of abdominal-A (abd-A) repression by Abdominal-B (Abd-B). Animals lacking Abd-B show ectopic expression of abd-A in the epidermis of the eighth abdominal segment, but not in the central nervous system. Repression in these neuronal cells is accomplished by a 92 kb noncoding RNA. This “iab-8 RNA” produces a micro RNA to repress abd-A, but also has a second, redundant repression mechanism that acts only “in cis.” Transcriptional interference with the abd-A promoter is the most likely mechanism. Public Library of Science 2012-05-24 /pmc/articles/PMC3359974/ /pubmed/22654672 http://dx.doi.org/10.1371/journal.pgen.1002720 Text en Gummalla et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Gummalla, Maheshwar
Maeda, Robert K.
Castro Alvarez, Javier J.
Gyurkovics, Henrik
Singari, Swetha
Edwards, Kevin A.
Karch, François
Bender, Welcome
abd-A Regulation by the iab-8 Noncoding RNA
title abd-A Regulation by the iab-8 Noncoding RNA
title_full abd-A Regulation by the iab-8 Noncoding RNA
title_fullStr abd-A Regulation by the iab-8 Noncoding RNA
title_full_unstemmed abd-A Regulation by the iab-8 Noncoding RNA
title_short abd-A Regulation by the iab-8 Noncoding RNA
title_sort abd-a regulation by the iab-8 noncoding rna
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359974/
https://www.ncbi.nlm.nih.gov/pubmed/22654672
http://dx.doi.org/10.1371/journal.pgen.1002720
work_keys_str_mv AT gummallamaheshwar abdaregulationbytheiab8noncodingrna
AT maedarobertk abdaregulationbytheiab8noncodingrna
AT castroalvarezjavierj abdaregulationbytheiab8noncodingrna
AT gyurkovicshenrik abdaregulationbytheiab8noncodingrna
AT singariswetha abdaregulationbytheiab8noncodingrna
AT edwardskevina abdaregulationbytheiab8noncodingrna
AT karchfrancois abdaregulationbytheiab8noncodingrna
AT benderwelcome abdaregulationbytheiab8noncodingrna