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abd-A Regulation by the iab-8 Noncoding RNA
The homeotic genes in Drosophila melanogaster are aligned on the chromosome in the order of the body segments that they affect. The genes affecting the more posterior segments repress the more anterior genes. This posterior dominance rule must be qualified in the case of abdominal-A (abd-A) repressi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359974/ https://www.ncbi.nlm.nih.gov/pubmed/22654672 http://dx.doi.org/10.1371/journal.pgen.1002720 |
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author | Gummalla, Maheshwar Maeda, Robert K. Castro Alvarez, Javier J. Gyurkovics, Henrik Singari, Swetha Edwards, Kevin A. Karch, François Bender, Welcome |
author_facet | Gummalla, Maheshwar Maeda, Robert K. Castro Alvarez, Javier J. Gyurkovics, Henrik Singari, Swetha Edwards, Kevin A. Karch, François Bender, Welcome |
author_sort | Gummalla, Maheshwar |
collection | PubMed |
description | The homeotic genes in Drosophila melanogaster are aligned on the chromosome in the order of the body segments that they affect. The genes affecting the more posterior segments repress the more anterior genes. This posterior dominance rule must be qualified in the case of abdominal-A (abd-A) repression by Abdominal-B (Abd-B). Animals lacking Abd-B show ectopic expression of abd-A in the epidermis of the eighth abdominal segment, but not in the central nervous system. Repression in these neuronal cells is accomplished by a 92 kb noncoding RNA. This “iab-8 RNA” produces a micro RNA to repress abd-A, but also has a second, redundant repression mechanism that acts only “in cis.” Transcriptional interference with the abd-A promoter is the most likely mechanism. |
format | Online Article Text |
id | pubmed-3359974 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-33599742012-05-31 abd-A Regulation by the iab-8 Noncoding RNA Gummalla, Maheshwar Maeda, Robert K. Castro Alvarez, Javier J. Gyurkovics, Henrik Singari, Swetha Edwards, Kevin A. Karch, François Bender, Welcome PLoS Genet Research Article The homeotic genes in Drosophila melanogaster are aligned on the chromosome in the order of the body segments that they affect. The genes affecting the more posterior segments repress the more anterior genes. This posterior dominance rule must be qualified in the case of abdominal-A (abd-A) repression by Abdominal-B (Abd-B). Animals lacking Abd-B show ectopic expression of abd-A in the epidermis of the eighth abdominal segment, but not in the central nervous system. Repression in these neuronal cells is accomplished by a 92 kb noncoding RNA. This “iab-8 RNA” produces a micro RNA to repress abd-A, but also has a second, redundant repression mechanism that acts only “in cis.” Transcriptional interference with the abd-A promoter is the most likely mechanism. Public Library of Science 2012-05-24 /pmc/articles/PMC3359974/ /pubmed/22654672 http://dx.doi.org/10.1371/journal.pgen.1002720 Text en Gummalla et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Gummalla, Maheshwar Maeda, Robert K. Castro Alvarez, Javier J. Gyurkovics, Henrik Singari, Swetha Edwards, Kevin A. Karch, François Bender, Welcome abd-A Regulation by the iab-8 Noncoding RNA |
title |
abd-A Regulation by the iab-8 Noncoding RNA |
title_full |
abd-A Regulation by the iab-8 Noncoding RNA |
title_fullStr |
abd-A Regulation by the iab-8 Noncoding RNA |
title_full_unstemmed |
abd-A Regulation by the iab-8 Noncoding RNA |
title_short |
abd-A Regulation by the iab-8 Noncoding RNA |
title_sort | abd-a regulation by the iab-8 noncoding rna |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359974/ https://www.ncbi.nlm.nih.gov/pubmed/22654672 http://dx.doi.org/10.1371/journal.pgen.1002720 |
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