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The dUTPase Enzyme Is Essential in Mycobacterium smegmatis

Thymidine biosynthesis is essential in all cells. Inhibitors of the enzymes involved in this pathway (e.g. methotrexate) are thus frequently used as cytostatics. Due to its pivotal role in mycobacterial thymidylate synthesis dUTPase, which hydrolyzes dUTP into the dTTP precursor dUMP, has been sugge...

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Detalles Bibliográficos
Autores principales:	Pecsi, Ildiko, Hirmondo, Rita, Brown, Amanda C., Lopata, Anna, Parish, Tanya, Vertessy, Beata G., Tóth, Judit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360063/ https://www.ncbi.nlm.nih.gov/pubmed/22655049 http://dx.doi.org/10.1371/journal.pone.0037461

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