Twist1 Suppresses Senescence Programs and Thereby Accelerates and Maintains Mutant Kras-Induced Lung Tumorigenesis

KRAS mutant lung cancers are generally refractory to chemotherapy as well targeted agents. To date, the identification of drugs to therapeutically inhibit K-RAS have been unsuccessful, suggesting that other approaches are required. We demonstrate in both a novel transgenic mutant Kras lung cancer mo...

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Detalles Bibliográficos
Autores principales: Tran, Phuoc T., Shroff, Emelyn H., Burns, Timothy F., Thiyagarajan, Saravanan, Das, Sandhya T., Zabuawala, Tahera, Chen, Joy, Cho, Yoon-Jae, Luong, Richard, Tamayo, Pablo, Salih, Tarek, Aziz, Khaled, Adam, Stacey J., Vicent, Silvestre, Nielsen, Carsten H., Withofs, Nadia, Sweet-Cordero, Alejandro, Gambhir, Sanjiv S., Rudin, Charles M., Felsher, Dean W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360067/
https://www.ncbi.nlm.nih.gov/pubmed/22654667
http://dx.doi.org/10.1371/journal.pgen.1002650

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