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Keratocystic Odontogenic Tumors: Predictive Factors of Recurrence by Ki-67 and AgNOR Labelling

Purpose: The purpose of the present study was to investigate the possible role of Ki-67 and argyrophilic nucleolar organizing regions (AgNOR) between the recurrent and nonrecurrent keratocystic odontogenic tumors (KCOTs). Another aim was to compare the correlation between these two markers. Material...

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Autores principales: Selvi, Firat, Tekkesin, Merva Soluk, Cakarer, Sirmahan, Isler, S. Cemil, Keskin, Cengizhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360429/
https://www.ncbi.nlm.nih.gov/pubmed/22639545
http://dx.doi.org/10.7150/ijms.4243
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author Selvi, Firat
Tekkesin, Merva Soluk
Cakarer, Sirmahan
Isler, S. Cemil
Keskin, Cengizhan
author_facet Selvi, Firat
Tekkesin, Merva Soluk
Cakarer, Sirmahan
Isler, S. Cemil
Keskin, Cengizhan
author_sort Selvi, Firat
collection PubMed
description Purpose: The purpose of the present study was to investigate the possible role of Ki-67 and argyrophilic nucleolar organizing regions (AgNOR) between the recurrent and nonrecurrent keratocystic odontogenic tumors (KCOTs). Another aim was to compare the correlation between these two markers. Materials and Methods: 22 KCOTs were evaluated retrospectively. The actual proliferative activity of the KCOT was measured by Ki-67 labelling index and argyrophilic nucleolar organizing regions AgNOR count per nucleus. Results: Recurrence occurred in 3 patients (13.6%) during the follow-up period (mean follow-up, 37.8 months) The Ki-67 and AgNOR counts were significantly higher in the recurrent lesions comparing to the non-recurrent lesions. (p=0,045; p=0,049) The correlation between Ki-67 and AgNOR counts was found to be positive (r=0,853 p=0,0001). Conclusion: Within the limit of the present study, it is thought that Ki-67 and AgNOR might be helpful as a prognostic marker for the recurrences of KCOTs. These markers reinforced the meaning of the new classification of the lesion as an odontogenic tumor. Enucleation with curettage or decompression following enucleation with curettage is a simple and appropriate surgical model for the treatment of KCOT despite the relative high recurrence rate. On the other hand, the conservative treatment can be chosen only if there is no coronoid invasion, no interruptive cortical lysis and no tissular invasion.
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spelling pubmed-33604292012-05-25 Keratocystic Odontogenic Tumors: Predictive Factors of Recurrence by Ki-67 and AgNOR Labelling Selvi, Firat Tekkesin, Merva Soluk Cakarer, Sirmahan Isler, S. Cemil Keskin, Cengizhan Int J Med Sci Research Paper Purpose: The purpose of the present study was to investigate the possible role of Ki-67 and argyrophilic nucleolar organizing regions (AgNOR) between the recurrent and nonrecurrent keratocystic odontogenic tumors (KCOTs). Another aim was to compare the correlation between these two markers. Materials and Methods: 22 KCOTs were evaluated retrospectively. The actual proliferative activity of the KCOT was measured by Ki-67 labelling index and argyrophilic nucleolar organizing regions AgNOR count per nucleus. Results: Recurrence occurred in 3 patients (13.6%) during the follow-up period (mean follow-up, 37.8 months) The Ki-67 and AgNOR counts were significantly higher in the recurrent lesions comparing to the non-recurrent lesions. (p=0,045; p=0,049) The correlation between Ki-67 and AgNOR counts was found to be positive (r=0,853 p=0,0001). Conclusion: Within the limit of the present study, it is thought that Ki-67 and AgNOR might be helpful as a prognostic marker for the recurrences of KCOTs. These markers reinforced the meaning of the new classification of the lesion as an odontogenic tumor. Enucleation with curettage or decompression following enucleation with curettage is a simple and appropriate surgical model for the treatment of KCOT despite the relative high recurrence rate. On the other hand, the conservative treatment can be chosen only if there is no coronoid invasion, no interruptive cortical lysis and no tissular invasion. Ivyspring International Publisher 2012-05-23 /pmc/articles/PMC3360429/ /pubmed/22639545 http://dx.doi.org/10.7150/ijms.4243 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Research Paper
Selvi, Firat
Tekkesin, Merva Soluk
Cakarer, Sirmahan
Isler, S. Cemil
Keskin, Cengizhan
Keratocystic Odontogenic Tumors: Predictive Factors of Recurrence by Ki-67 and AgNOR Labelling
title Keratocystic Odontogenic Tumors: Predictive Factors of Recurrence by Ki-67 and AgNOR Labelling
title_full Keratocystic Odontogenic Tumors: Predictive Factors of Recurrence by Ki-67 and AgNOR Labelling
title_fullStr Keratocystic Odontogenic Tumors: Predictive Factors of Recurrence by Ki-67 and AgNOR Labelling
title_full_unstemmed Keratocystic Odontogenic Tumors: Predictive Factors of Recurrence by Ki-67 and AgNOR Labelling
title_short Keratocystic Odontogenic Tumors: Predictive Factors of Recurrence by Ki-67 and AgNOR Labelling
title_sort keratocystic odontogenic tumors: predictive factors of recurrence by ki-67 and agnor labelling
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360429/
https://www.ncbi.nlm.nih.gov/pubmed/22639545
http://dx.doi.org/10.7150/ijms.4243
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