Pan-Pathway Based Interaction Profiling of FDA-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism

To identify interactions a nucleoside analog library (NAL) consisting of 45 FDA-approved nucleoside analogs was screened against 23 enzymes of the human nucleotide metabolism using a thermal shift assay. The method was validated with deoxycytidine kinase; eight interactions known from the literature...

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Detalles Bibliográficos
Autores principales: Egeblad, Louise, Welin, Martin, Flodin, Susanne, Gräslund, Susanne, Wang, Liya, Balzarini, Jan, Eriksson, Staffan, Nordlund, Pär
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360617/
https://www.ncbi.nlm.nih.gov/pubmed/22662200
http://dx.doi.org/10.1371/journal.pone.0037724

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