pKa Modulation of the Acid/Base Catalyst within GH32 and GH68: A Role in Substrate/Inhibitor Specificity?

Glycoside hydrolases of families 32 (GH32) and 68 (GH68) belong to clan GH-J, containing hydrolytic enzymes (sucrose/fructans as donor substrates) and fructosyltransferases (sucrose/fructans as donor and acceptor substrates). In GH32 members, some of the sugar substrates can also function as inhibit...

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Detalles Bibliográficos
Autores principales: Yuan, Shuguang, Le Roy, Katrien, Venken, Tom, Lammens, Willem, Van den Ende, Wim, De Maeyer, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360783/
https://www.ncbi.nlm.nih.gov/pubmed/22662155
http://dx.doi.org/10.1371/journal.pone.0037453

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