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Pathological complete response in younger and older breast cancer patients
INTRODUCTION: Pathologic complete response (pCR) after neoadjuvant systemic treatment for inoperable locally advanced breast cancer is defined as complete microscopic disappearance of invasive cancer in both the breast and axilla in the postoperative specimen. The aim of the study was to characteriz...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361044/ https://www.ncbi.nlm.nih.gov/pubmed/22662005 http://dx.doi.org/10.5114/aoms.2012.28559 |
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author | Kołacińska, Agnieszka Chałubińska, Justyna Błasińska-Morawiec, Maria Dowgier-Witczak, Izabela Fendler, Wojciech Kordek, Radzisław Morawiec, Zbigniew |
author_facet | Kołacińska, Agnieszka Chałubińska, Justyna Błasińska-Morawiec, Maria Dowgier-Witczak, Izabela Fendler, Wojciech Kordek, Radzisław Morawiec, Zbigniew |
author_sort | Kołacińska, Agnieszka |
collection | PubMed |
description | INTRODUCTION: Pathologic complete response (pCR) after neoadjuvant systemic treatment for inoperable locally advanced breast cancer is defined as complete microscopic disappearance of invasive cancer in both the breast and axilla in the postoperative specimen. The aim of the study was to characterize the groups of younger (≤ 40 years old) and older (≥ 70 years old) breast cancer patients who achieved a pCR. MATERIAL AND METHODS: One hundred thirty-eight consecutive patients aged between 30 and 78 years with locally advanced breast cancer, operated on after neoadjuvant systemic treatment between November 2007 and June 2010, were analyzed. In this group 9 women (6.5%) were 40 years of age or younger, and 12 patients (8.7%) were 70 years of age or older. RESULTS: In the younger group, pCR was achieved in 1 patient with triple negative, invasive ductal breast cancer, G3, BRCA 1 mutation, treated with cisplatin. A near pCR was achieved in 2 other patients, with triple negative, invasive ductal breast cancer, G3, treated with AT. The pCR in the breast was found in a HER2 positive patient. In older patients, pCR was achieved in 2 patients with triple negative, invasive ductal breast cancer, G3, treated with AT or FEC. Pathologic complete response in the axilla was achieved in 1 patient with triple negative, ductal carcinoma. The pCR rates were significantly higher in triple negative breast cancer in both groups (p = 0.047 and p = 0.018, respectively). CONCLUSIONS: Pathologic complete response was significantly associated with receptor- based subtypes in both young and old women. |
format | Online Article Text |
id | pubmed-3361044 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-33610442012-06-01 Pathological complete response in younger and older breast cancer patients Kołacińska, Agnieszka Chałubińska, Justyna Błasińska-Morawiec, Maria Dowgier-Witczak, Izabela Fendler, Wojciech Kordek, Radzisław Morawiec, Zbigniew Arch Med Sci Clinical Research INTRODUCTION: Pathologic complete response (pCR) after neoadjuvant systemic treatment for inoperable locally advanced breast cancer is defined as complete microscopic disappearance of invasive cancer in both the breast and axilla in the postoperative specimen. The aim of the study was to characterize the groups of younger (≤ 40 years old) and older (≥ 70 years old) breast cancer patients who achieved a pCR. MATERIAL AND METHODS: One hundred thirty-eight consecutive patients aged between 30 and 78 years with locally advanced breast cancer, operated on after neoadjuvant systemic treatment between November 2007 and June 2010, were analyzed. In this group 9 women (6.5%) were 40 years of age or younger, and 12 patients (8.7%) were 70 years of age or older. RESULTS: In the younger group, pCR was achieved in 1 patient with triple negative, invasive ductal breast cancer, G3, BRCA 1 mutation, treated with cisplatin. A near pCR was achieved in 2 other patients, with triple negative, invasive ductal breast cancer, G3, treated with AT. The pCR in the breast was found in a HER2 positive patient. In older patients, pCR was achieved in 2 patients with triple negative, invasive ductal breast cancer, G3, treated with AT or FEC. Pathologic complete response in the axilla was achieved in 1 patient with triple negative, ductal carcinoma. The pCR rates were significantly higher in triple negative breast cancer in both groups (p = 0.047 and p = 0.018, respectively). CONCLUSIONS: Pathologic complete response was significantly associated with receptor- based subtypes in both young and old women. Termedia Publishing House 2012-05-09 2012-05-09 /pmc/articles/PMC3361044/ /pubmed/22662005 http://dx.doi.org/10.5114/aoms.2012.28559 Text en Copyright © 2012 Termedia & Banach http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Research Kołacińska, Agnieszka Chałubińska, Justyna Błasińska-Morawiec, Maria Dowgier-Witczak, Izabela Fendler, Wojciech Kordek, Radzisław Morawiec, Zbigniew Pathological complete response in younger and older breast cancer patients |
title | Pathological complete response in younger and older breast cancer patients |
title_full | Pathological complete response in younger and older breast cancer patients |
title_fullStr | Pathological complete response in younger and older breast cancer patients |
title_full_unstemmed | Pathological complete response in younger and older breast cancer patients |
title_short | Pathological complete response in younger and older breast cancer patients |
title_sort | pathological complete response in younger and older breast cancer patients |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361044/ https://www.ncbi.nlm.nih.gov/pubmed/22662005 http://dx.doi.org/10.5114/aoms.2012.28559 |
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