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GABA-A receptor genes do not play a role in genetics of Lesch's typology in Caucasian subjects

INTRODUCTION: Lesch's typology differentiates alcoholics into different treatment response subgroups. The effects of ethanol are mediated, to an important extent, via the GABA-ergic system. MATERIAL AND METHODS: We have evaluated the linkage disequilibrium patterns and haplotype frequencies of...

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Detalles Bibliográficos
Autores principales: Grzywacz, Anna, Małecka, Iwona, Korostyński, Michał, Przewłocki, Ryszard, Bieńkowski, Przemysław, Samochowiec, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361050/
https://www.ncbi.nlm.nih.gov/pubmed/22662011
http://dx.doi.org/10.5114/aoms.2012.28565
Descripción
Sumario:INTRODUCTION: Lesch's typology differentiates alcoholics into different treatment response subgroups. The effects of ethanol are mediated, to an important extent, via the GABA-ergic system. MATERIAL AND METHODS: We have evaluated the linkage disequilibrium patterns and haplotype frequencies of GABRG1 and GABRA2 genes in 133 alcoholics divided according to Lesch's typology and in 145 matched controls. RESULTS: Besides several relationships at a threshold of statistical significance, we found no significant differences in the haplotype distribution of these genes between alcoholics and controls. CONCLUSIONS: Lesch's typology may not be related with the genotype of alcoholics – at least in terms of genes with an established role in the development of dependency.