GABA-A receptor genes do not play a role in genetics of Lesch's typology in Caucasian subjects

INTRODUCTION: Lesch's typology differentiates alcoholics into different treatment response subgroups. The effects of ethanol are mediated, to an important extent, via the GABA-ergic system. MATERIAL AND METHODS: We have evaluated the linkage disequilibrium patterns and haplotype frequencies of...

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Autores principales: Grzywacz, Anna, Małecka, Iwona, Korostyński, Michał, Przewłocki, Ryszard, Bieńkowski, Przemysław, Samochowiec, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2012
Materias:
Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361050/
https://www.ncbi.nlm.nih.gov/pubmed/22662011
http://dx.doi.org/10.5114/aoms.2012.28565
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author Grzywacz, Anna
Małecka, Iwona
Korostyński, Michał
Przewłocki, Ryszard
Bieńkowski, Przemysław
Samochowiec, Jerzy
author_facet Grzywacz, Anna
Małecka, Iwona
Korostyński, Michał
Przewłocki, Ryszard
Bieńkowski, Przemysław
Samochowiec, Jerzy
author_sort Grzywacz, Anna
collection PubMed
description INTRODUCTION: Lesch's typology differentiates alcoholics into different treatment response subgroups. The effects of ethanol are mediated, to an important extent, via the GABA-ergic system. MATERIAL AND METHODS: We have evaluated the linkage disequilibrium patterns and haplotype frequencies of GABRG1 and GABRA2 genes in 133 alcoholics divided according to Lesch's typology and in 145 matched controls. RESULTS: Besides several relationships at a threshold of statistical significance, we found no significant differences in the haplotype distribution of these genes between alcoholics and controls. CONCLUSIONS: Lesch's typology may not be related with the genotype of alcoholics – at least in terms of genes with an established role in the development of dependency.
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spelling pubmed-33610502012-06-01 GABA-A receptor genes do not play a role in genetics of Lesch's typology in Caucasian subjects Grzywacz, Anna Małecka, Iwona Korostyński, Michał Przewłocki, Ryszard Bieńkowski, Przemysław Samochowiec, Jerzy Arch Med Sci Clinical Research INTRODUCTION: Lesch's typology differentiates alcoholics into different treatment response subgroups. The effects of ethanol are mediated, to an important extent, via the GABA-ergic system. MATERIAL AND METHODS: We have evaluated the linkage disequilibrium patterns and haplotype frequencies of GABRG1 and GABRA2 genes in 133 alcoholics divided according to Lesch's typology and in 145 matched controls. RESULTS: Besides several relationships at a threshold of statistical significance, we found no significant differences in the haplotype distribution of these genes between alcoholics and controls. CONCLUSIONS: Lesch's typology may not be related with the genotype of alcoholics – at least in terms of genes with an established role in the development of dependency. Termedia Publishing House 2012-05-09 2012-05-09 /pmc/articles/PMC3361050/ /pubmed/22662011 http://dx.doi.org/10.5114/aoms.2012.28565 Text en Copyright © 2012 Termedia & Banach http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research
Grzywacz, Anna
Małecka, Iwona
Korostyński, Michał
Przewłocki, Ryszard
Bieńkowski, Przemysław
Samochowiec, Jerzy
GABA-A receptor genes do not play a role in genetics of Lesch's typology in Caucasian subjects
title GABA-A receptor genes do not play a role in genetics of Lesch's typology in Caucasian subjects
title_full GABA-A receptor genes do not play a role in genetics of Lesch's typology in Caucasian subjects
title_fullStr GABA-A receptor genes do not play a role in genetics of Lesch's typology in Caucasian subjects
title_full_unstemmed GABA-A receptor genes do not play a role in genetics of Lesch's typology in Caucasian subjects
title_short GABA-A receptor genes do not play a role in genetics of Lesch's typology in Caucasian subjects
title_sort gaba-a receptor genes do not play a role in genetics of lesch's typology in caucasian subjects
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361050/
https://www.ncbi.nlm.nih.gov/pubmed/22662011
http://dx.doi.org/10.5114/aoms.2012.28565
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