Differing Von Hippel Lindau Genotype in Paired Primary and Metastatic Tumors in Patients with Clear Cell Renal Cell Carcinoma

In sporadic clear cell renal cell carcinoma (CCRCC), the von Hippel Lindau (VHL) gene is inactivated by mutation or methylation in the majority of primary (P) tumors. Due to differing effects of wild-type (WT) and mutant (MT) VHL gene on downstream signaling pathways regulating angiogenesis, VHL gen...

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Detalles Bibliográficos
Autores principales: Vaziri, Susan A. J., Tavares, Emmanuel J., Golshayan, Ali R., Rini, Brian I., Aydin, Hakan, Zhou, Ming, Sercia, Linda, Wood, Laura, Ganapathi, Mahrukh K., Bukowski, Ronald M., Ganapathi, Ram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361062/
https://www.ncbi.nlm.nih.gov/pubmed/22655276
http://dx.doi.org/10.3389/fonc.2012.00051

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