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Combined Effect of Subchondral Drilling and Hyaluronic Acid with/without Diacerein in Full-Thickness Articular Cartilage Lesion in Rabbits

The osteochondral healing potential of hyaluronic acid (HA) plus diacerein was evaluated in subchondral-drilling- (SCD-) induced fibrocartilage generation in rabbits. A full-thickness chondral defect was created along the patellar groove of both knees and then SCD was subsequently performed only in...

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Autores principales: Suwannaloet, Wanwisa, Laupattarakasem, Wiroon, Sukon, Peerapol, Ong-Chai, Siriwan, Laupattarakasem, Pisamai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific World Journal 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361165/
https://www.ncbi.nlm.nih.gov/pubmed/22666105
http://dx.doi.org/10.1100/2012/310745
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author Suwannaloet, Wanwisa
Laupattarakasem, Wiroon
Sukon, Peerapol
Ong-Chai, Siriwan
Laupattarakasem, Pisamai
author_facet Suwannaloet, Wanwisa
Laupattarakasem, Wiroon
Sukon, Peerapol
Ong-Chai, Siriwan
Laupattarakasem, Pisamai
author_sort Suwannaloet, Wanwisa
collection PubMed
description The osteochondral healing potential of hyaluronic acid (HA) plus diacerein was evaluated in subchondral-drilling- (SCD-) induced fibrocartilage generation in rabbits. A full-thickness chondral defect was created along the patellar groove of both knees and then SCD was subsequently performed only in the left knee. A week later, the rabbits were allocated into 3 groups to receive weekly intra-articular (IA) injection for 5 weeks with normal saline solution (NSS) (group 1) or with HA (group 2 and group 3). Starting at the first IA injection, rabbits were also gavaged daily for 9 weeks with NSS (group 1 and group 2) or with diacerein (group 3). The animals were then sacrificed for evaluation. The newly formed tissue in SCD lesions showed significantly better histological grading scale and had higher content of type II collagen in HA-treated group compared to NSS control. In addition, adding oral diacerein to HA injection enhanced healing potential of HA.
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spelling pubmed-33611652012-06-04 Combined Effect of Subchondral Drilling and Hyaluronic Acid with/without Diacerein in Full-Thickness Articular Cartilage Lesion in Rabbits Suwannaloet, Wanwisa Laupattarakasem, Wiroon Sukon, Peerapol Ong-Chai, Siriwan Laupattarakasem, Pisamai ScientificWorldJournal Research Article The osteochondral healing potential of hyaluronic acid (HA) plus diacerein was evaluated in subchondral-drilling- (SCD-) induced fibrocartilage generation in rabbits. A full-thickness chondral defect was created along the patellar groove of both knees and then SCD was subsequently performed only in the left knee. A week later, the rabbits were allocated into 3 groups to receive weekly intra-articular (IA) injection for 5 weeks with normal saline solution (NSS) (group 1) or with HA (group 2 and group 3). Starting at the first IA injection, rabbits were also gavaged daily for 9 weeks with NSS (group 1 and group 2) or with diacerein (group 3). The animals were then sacrificed for evaluation. The newly formed tissue in SCD lesions showed significantly better histological grading scale and had higher content of type II collagen in HA-treated group compared to NSS control. In addition, adding oral diacerein to HA injection enhanced healing potential of HA. The Scientific World Journal 2012-04-30 /pmc/articles/PMC3361165/ /pubmed/22666105 http://dx.doi.org/10.1100/2012/310745 Text en Copyright © 2012 Wanwisa Suwannaloet et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Suwannaloet, Wanwisa
Laupattarakasem, Wiroon
Sukon, Peerapol
Ong-Chai, Siriwan
Laupattarakasem, Pisamai
Combined Effect of Subchondral Drilling and Hyaluronic Acid with/without Diacerein in Full-Thickness Articular Cartilage Lesion in Rabbits
title Combined Effect of Subchondral Drilling and Hyaluronic Acid with/without Diacerein in Full-Thickness Articular Cartilage Lesion in Rabbits
title_full Combined Effect of Subchondral Drilling and Hyaluronic Acid with/without Diacerein in Full-Thickness Articular Cartilage Lesion in Rabbits
title_fullStr Combined Effect of Subchondral Drilling and Hyaluronic Acid with/without Diacerein in Full-Thickness Articular Cartilage Lesion in Rabbits
title_full_unstemmed Combined Effect of Subchondral Drilling and Hyaluronic Acid with/without Diacerein in Full-Thickness Articular Cartilage Lesion in Rabbits
title_short Combined Effect of Subchondral Drilling and Hyaluronic Acid with/without Diacerein in Full-Thickness Articular Cartilage Lesion in Rabbits
title_sort combined effect of subchondral drilling and hyaluronic acid with/without diacerein in full-thickness articular cartilage lesion in rabbits
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361165/
https://www.ncbi.nlm.nih.gov/pubmed/22666105
http://dx.doi.org/10.1100/2012/310745
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