Cargando…
Antioxidant Effect of MnTE-2-PyP on Lung in Asthma Mice Model
Aim. To investigate the effects of MnTE-2-PyP on some markers of antioxidant defence system in asthma mice model. Material and Methods. The animals were divided into four groups: group 1, controls; group 2, injected with ovalbumin, group 3, treated with MnTE-2-PyP, and group 4, treated with ovalbumi...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Scientific World Journal
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361234/ https://www.ncbi.nlm.nih.gov/pubmed/22654599 http://dx.doi.org/10.1100/2012/379360 |
_version_ | 1782234104011423744 |
---|---|
author | Terziev, Lyudmil Dancheva, Violeta Shopova, Veneta Stavreva, Galya |
author_facet | Terziev, Lyudmil Dancheva, Violeta Shopova, Veneta Stavreva, Galya |
author_sort | Terziev, Lyudmil |
collection | PubMed |
description | Aim. To investigate the effects of MnTE-2-PyP on some markers of antioxidant defence system in asthma mice model. Material and Methods. The animals were divided into four groups: group 1, controls; group 2, injected with ovalbumin, group 3, treated with MnTE-2-PyP, and group 4, treated with ovalbumin and MnTE-2-PyP. The activities of superoxide dismutase, catalase, glutathione peroxidase and nonprotein sulfhydryl groups content (NPSH) were determined in lung homogenate. Results. The activities of superoxide dismutase and catalase in group 2 decreased significantly as compared to control group. The decrease of the same enzymes in group 4 was lower and significant as compared to group 2. Changes in the glutathione peroxidase activity showed a similar dynamics. The NPSH groups content decreased in group 2. In group 4 this decrease was relatively lower as compared to group 2. Conclusions. The application of MnTE-2-PyP mitigated the effects of oxidative stress in asthma mice model. |
format | Online Article Text |
id | pubmed-3361234 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Scientific World Journal |
record_format | MEDLINE/PubMed |
spelling | pubmed-33612342012-05-31 Antioxidant Effect of MnTE-2-PyP on Lung in Asthma Mice Model Terziev, Lyudmil Dancheva, Violeta Shopova, Veneta Stavreva, Galya ScientificWorldJournal Research Article Aim. To investigate the effects of MnTE-2-PyP on some markers of antioxidant defence system in asthma mice model. Material and Methods. The animals were divided into four groups: group 1, controls; group 2, injected with ovalbumin, group 3, treated with MnTE-2-PyP, and group 4, treated with ovalbumin and MnTE-2-PyP. The activities of superoxide dismutase, catalase, glutathione peroxidase and nonprotein sulfhydryl groups content (NPSH) were determined in lung homogenate. Results. The activities of superoxide dismutase and catalase in group 2 decreased significantly as compared to control group. The decrease of the same enzymes in group 4 was lower and significant as compared to group 2. Changes in the glutathione peroxidase activity showed a similar dynamics. The NPSH groups content decreased in group 2. In group 4 this decrease was relatively lower as compared to group 2. Conclusions. The application of MnTE-2-PyP mitigated the effects of oxidative stress in asthma mice model. The Scientific World Journal 2012-04-30 /pmc/articles/PMC3361234/ /pubmed/22654599 http://dx.doi.org/10.1100/2012/379360 Text en Copyright © 2012 Lyudmil Terziev et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Terziev, Lyudmil Dancheva, Violeta Shopova, Veneta Stavreva, Galya Antioxidant Effect of MnTE-2-PyP on Lung in Asthma Mice Model |
title | Antioxidant Effect of MnTE-2-PyP on Lung in Asthma Mice Model |
title_full | Antioxidant Effect of MnTE-2-PyP on Lung in Asthma Mice Model |
title_fullStr | Antioxidant Effect of MnTE-2-PyP on Lung in Asthma Mice Model |
title_full_unstemmed | Antioxidant Effect of MnTE-2-PyP on Lung in Asthma Mice Model |
title_short | Antioxidant Effect of MnTE-2-PyP on Lung in Asthma Mice Model |
title_sort | antioxidant effect of mnte-2-pyp on lung in asthma mice model |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361234/ https://www.ncbi.nlm.nih.gov/pubmed/22654599 http://dx.doi.org/10.1100/2012/379360 |
work_keys_str_mv | AT terzievlyudmil antioxidanteffectofmnte2pyponlunginasthmamicemodel AT danchevavioleta antioxidanteffectofmnte2pyponlunginasthmamicemodel AT shopovaveneta antioxidanteffectofmnte2pyponlunginasthmamicemodel AT stavrevagalya antioxidanteffectofmnte2pyponlunginasthmamicemodel |