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Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD
Introduction and Hypothesis. Some papers have shown that bone mineral density (BMD) may not be accurate in predicting fracture risk. Recently microarchitecture parameters have been reported to give information on bone characteristics. The aim of this study was to find out if the values of volume, fr...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Scientific World Journal
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361288/ https://www.ncbi.nlm.nih.gov/pubmed/22654618 http://dx.doi.org/10.1100/2012/502781 |
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author | Topoliński, Tomasz Mazurkiewicz, Adam Jung, Stanislaw Cichański, Artur Nowicki, Krzysztof |
author_facet | Topoliński, Tomasz Mazurkiewicz, Adam Jung, Stanislaw Cichański, Artur Nowicki, Krzysztof |
author_sort | Topoliński, Tomasz |
collection | PubMed |
description | Introduction and Hypothesis. Some papers have shown that bone mineral density (BMD) may not be accurate in predicting fracture risk. Recently microarchitecture parameters have been reported to give information on bone characteristics. The aim of this study was to find out if the values of volume, fractal dimension, and bone mineral density are correlated with bone strength. Methods. Forty-two human bone samples harvested during total hip replacement surgery were cut to cylindrical samples. The geometrical mesh of layers of bone mass obtained from microCT investigation and the volumes of each layer and fractal dimension were calculated. The finite element method was applied to calculate the compression force F causing ε = 0.8% strain. Results. There were stronger correlations for microarchitecture parameters with strength than those for bone mineral density. The values of determination coefficient R (2) for mean volume and force were 0.88 and 0.90 for mean fractal dimension and force, while for BMD and force the value was 0.53. The samples with bigger mean bone volume of layers and bigger mean fractal dimension of layers (more complex structure) presented higher strength. Conclusion. The volumetric and fractal dimension parameters better describe bone structure and strength than BMD. |
format | Online Article Text |
id | pubmed-3361288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Scientific World Journal |
record_format | MEDLINE/PubMed |
spelling | pubmed-33612882012-05-31 Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD Topoliński, Tomasz Mazurkiewicz, Adam Jung, Stanislaw Cichański, Artur Nowicki, Krzysztof ScientificWorldJournal Research Article Introduction and Hypothesis. Some papers have shown that bone mineral density (BMD) may not be accurate in predicting fracture risk. Recently microarchitecture parameters have been reported to give information on bone characteristics. The aim of this study was to find out if the values of volume, fractal dimension, and bone mineral density are correlated with bone strength. Methods. Forty-two human bone samples harvested during total hip replacement surgery were cut to cylindrical samples. The geometrical mesh of layers of bone mass obtained from microCT investigation and the volumes of each layer and fractal dimension were calculated. The finite element method was applied to calculate the compression force F causing ε = 0.8% strain. Results. There were stronger correlations for microarchitecture parameters with strength than those for bone mineral density. The values of determination coefficient R (2) for mean volume and force were 0.88 and 0.90 for mean fractal dimension and force, while for BMD and force the value was 0.53. The samples with bigger mean bone volume of layers and bigger mean fractal dimension of layers (more complex structure) presented higher strength. Conclusion. The volumetric and fractal dimension parameters better describe bone structure and strength than BMD. The Scientific World Journal 2012-05-01 /pmc/articles/PMC3361288/ /pubmed/22654618 http://dx.doi.org/10.1100/2012/502781 Text en Copyright © 2012 Tomasz Topoliński et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Topoliński, Tomasz Mazurkiewicz, Adam Jung, Stanislaw Cichański, Artur Nowicki, Krzysztof Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD |
title | Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD |
title_full | Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD |
title_fullStr | Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD |
title_full_unstemmed | Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD |
title_short | Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD |
title_sort | microarchitecture parameters describe bone structure and its strength better than bmd |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361288/ https://www.ncbi.nlm.nih.gov/pubmed/22654618 http://dx.doi.org/10.1100/2012/502781 |
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