Cargando…

Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD

Introduction and Hypothesis. Some papers have shown that bone mineral density (BMD) may not be accurate in predicting fracture risk. Recently microarchitecture parameters have been reported to give information on bone characteristics. The aim of this study was to find out if the values of volume, fr...

Descripción completa

Detalles Bibliográficos
Autores principales: Topoliński, Tomasz, Mazurkiewicz, Adam, Jung, Stanislaw, Cichański, Artur, Nowicki, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific World Journal 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361288/
https://www.ncbi.nlm.nih.gov/pubmed/22654618
http://dx.doi.org/10.1100/2012/502781
_version_ 1782234115983015936
author Topoliński, Tomasz
Mazurkiewicz, Adam
Jung, Stanislaw
Cichański, Artur
Nowicki, Krzysztof
author_facet Topoliński, Tomasz
Mazurkiewicz, Adam
Jung, Stanislaw
Cichański, Artur
Nowicki, Krzysztof
author_sort Topoliński, Tomasz
collection PubMed
description Introduction and Hypothesis. Some papers have shown that bone mineral density (BMD) may not be accurate in predicting fracture risk. Recently microarchitecture parameters have been reported to give information on bone characteristics. The aim of this study was to find out if the values of volume, fractal dimension, and bone mineral density are correlated with bone strength. Methods. Forty-two human bone samples harvested during total hip replacement surgery were cut to cylindrical samples. The geometrical mesh of layers of bone mass obtained from microCT investigation and the volumes of each layer and fractal dimension were calculated. The finite element method was applied to calculate the compression force F causing ε = 0.8% strain. Results. There were stronger correlations for microarchitecture parameters with strength than those for bone mineral density. The values of determination coefficient R (2) for mean volume and force were 0.88 and 0.90 for mean fractal dimension and force, while for BMD and force the value was 0.53. The samples with bigger mean bone volume of layers and bigger mean fractal dimension of layers (more complex structure) presented higher strength. Conclusion. The volumetric and fractal dimension parameters better describe bone structure and strength than BMD.
format Online
Article
Text
id pubmed-3361288
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher The Scientific World Journal
record_format MEDLINE/PubMed
spelling pubmed-33612882012-05-31 Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD Topoliński, Tomasz Mazurkiewicz, Adam Jung, Stanislaw Cichański, Artur Nowicki, Krzysztof ScientificWorldJournal Research Article Introduction and Hypothesis. Some papers have shown that bone mineral density (BMD) may not be accurate in predicting fracture risk. Recently microarchitecture parameters have been reported to give information on bone characteristics. The aim of this study was to find out if the values of volume, fractal dimension, and bone mineral density are correlated with bone strength. Methods. Forty-two human bone samples harvested during total hip replacement surgery were cut to cylindrical samples. The geometrical mesh of layers of bone mass obtained from microCT investigation and the volumes of each layer and fractal dimension were calculated. The finite element method was applied to calculate the compression force F causing ε = 0.8% strain. Results. There were stronger correlations for microarchitecture parameters with strength than those for bone mineral density. The values of determination coefficient R (2) for mean volume and force were 0.88 and 0.90 for mean fractal dimension and force, while for BMD and force the value was 0.53. The samples with bigger mean bone volume of layers and bigger mean fractal dimension of layers (more complex structure) presented higher strength. Conclusion. The volumetric and fractal dimension parameters better describe bone structure and strength than BMD. The Scientific World Journal 2012-05-01 /pmc/articles/PMC3361288/ /pubmed/22654618 http://dx.doi.org/10.1100/2012/502781 Text en Copyright © 2012 Tomasz Topoliński et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Topoliński, Tomasz
Mazurkiewicz, Adam
Jung, Stanislaw
Cichański, Artur
Nowicki, Krzysztof
Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD
title Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD
title_full Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD
title_fullStr Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD
title_full_unstemmed Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD
title_short Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD
title_sort microarchitecture parameters describe bone structure and its strength better than bmd
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361288/
https://www.ncbi.nlm.nih.gov/pubmed/22654618
http://dx.doi.org/10.1100/2012/502781
work_keys_str_mv AT topolinskitomasz microarchitectureparametersdescribebonestructureanditsstrengthbetterthanbmd
AT mazurkiewiczadam microarchitectureparametersdescribebonestructureanditsstrengthbetterthanbmd
AT jungstanislaw microarchitectureparametersdescribebonestructureanditsstrengthbetterthanbmd
AT cichanskiartur microarchitectureparametersdescribebonestructureanditsstrengthbetterthanbmd
AT nowickikrzysztof microarchitectureparametersdescribebonestructureanditsstrengthbetterthanbmd