Markers of Field Cancerization: Proposed Clinical Applications in Prostate Biopsies

Field cancerization denotes the occurrence of genetic, epigenetic, and biochemical aberrations in structurally intact cells in histologically normal tissues adjacent to cancerous lesions. This paper tabulates markers of prostate field cancerization known to date and discusses their potential clinica...

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Detalles Bibliográficos
Autores principales: Trujillo, Kristina A., Jones, Anna C., Griffith, Jeffrey K., Bisoffi, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361299/
https://www.ncbi.nlm.nih.gov/pubmed/22666601
http://dx.doi.org/10.1155/2012/302894
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author Trujillo, Kristina A.
Jones, Anna C.
Griffith, Jeffrey K.
Bisoffi, Marco
author_facet Trujillo, Kristina A.
Jones, Anna C.
Griffith, Jeffrey K.
Bisoffi, Marco
author_sort Trujillo, Kristina A.
collection PubMed
description Field cancerization denotes the occurrence of genetic, epigenetic, and biochemical aberrations in structurally intact cells in histologically normal tissues adjacent to cancerous lesions. This paper tabulates markers of prostate field cancerization known to date and discusses their potential clinical value in the analysis of prostate biopsies, including diagnosis, monitoring progression during active surveillance, and assessing efficacy of presurgical neoadjuvant and focal therapeutic interventions.
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spelling pubmed-33612992012-06-04 Markers of Field Cancerization: Proposed Clinical Applications in Prostate Biopsies Trujillo, Kristina A. Jones, Anna C. Griffith, Jeffrey K. Bisoffi, Marco Prostate Cancer Review Article Field cancerization denotes the occurrence of genetic, epigenetic, and biochemical aberrations in structurally intact cells in histologically normal tissues adjacent to cancerous lesions. This paper tabulates markers of prostate field cancerization known to date and discusses their potential clinical value in the analysis of prostate biopsies, including diagnosis, monitoring progression during active surveillance, and assessing efficacy of presurgical neoadjuvant and focal therapeutic interventions. Hindawi Publishing Corporation 2012 2012-05-14 /pmc/articles/PMC3361299/ /pubmed/22666601 http://dx.doi.org/10.1155/2012/302894 Text en Copyright © 2012 Kristina A. Trujillo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Trujillo, Kristina A.
Jones, Anna C.
Griffith, Jeffrey K.
Bisoffi, Marco
Markers of Field Cancerization: Proposed Clinical Applications in Prostate Biopsies
title Markers of Field Cancerization: Proposed Clinical Applications in Prostate Biopsies
title_full Markers of Field Cancerization: Proposed Clinical Applications in Prostate Biopsies
title_fullStr Markers of Field Cancerization: Proposed Clinical Applications in Prostate Biopsies
title_full_unstemmed Markers of Field Cancerization: Proposed Clinical Applications in Prostate Biopsies
title_short Markers of Field Cancerization: Proposed Clinical Applications in Prostate Biopsies
title_sort markers of field cancerization: proposed clinical applications in prostate biopsies
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361299/
https://www.ncbi.nlm.nih.gov/pubmed/22666601
http://dx.doi.org/10.1155/2012/302894
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