Cargando…

Features of “All LNA” Duplexes Showing a New Type of Nucleic Acid Geometry

“Locked nucleic acids” (LNAs) belong to the backbone-modified nucleic acid family. The 2′-O,4′-C-methylene-β-D-ribofuranose nucleotides are used for single or multiple substitutions in RNA molecules and thereby introduce enhanced bio- and thermostability. This renders LNAs powerful tools for diagnos...

Descripción completa

Detalles Bibliográficos
Autores principales:	Förster, Charlotte, Eichert, André, Oberthür, Dominik, Betzel, Christian, Geßner, Reinhard, Nitsche, Andreas, Fürste, Jens P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361345/ https://www.ncbi.nlm.nih.gov/pubmed/22666550 http://dx.doi.org/10.1155/2012/156035

Ejemplares similares

The crystal structure of an ‘All Locked’ nucleic acid duplex
por: Eichert, André, et al.
Publicado: (2010)

Next-generation bis-locked nucleic acids with stacking linker and 2′-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes
por: Geny, Sylvain, et al.
Publicado: (2016)

Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA
por: Moreno, Pedro M. D., et al.
Publicado: (2013)

Insights into structure, dynamics and hydration of locked nucleic acid (LNA) strand-based duplexes from molecular dynamics simulations
por: Pande, Vineet, et al.
Publicado: (2008)

Discovery of herpesviruses in multi-infected primates using locked nucleic acids (LNA) and a bigenic PCR approach
por: Prepens, Sandra, et al.
Publicado: (2007)

Optimizing anti-gene oligonucleotide ‘Zorro-LNA’ for improved strand invasion into duplex DNA
por: Zaghloul, Eman M., et al.
Publicado: (2011)

Increased duplex stabilization in porphyrin-LNA zipper arrays with structure dependent exciton coupling
por: Singleton, Daniel G., et al.
Publicado: (2016)

LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures
por: Pabon-Martinez, Y. Vladimir, et al.
Publicado: (2017)

NMR solution structures of LNA (locked nucleic acid) modified quadruplexes
por: Nielsen, Jakob T., et al.
Publicado: (2006)

LNA units present in [R(P)-PS]-(DNA#LNA) chimeras enhance the thermal stability of parallel duplexes and triplexes formed with (2′-OMe)-RNA strands
por: Jastrzębska, Katarzyna, et al.
Publicado: (2020)

Synthesis and Excellent Duplex Stability of Oligonucleotides Containing 2′-Amino-LNA Functionalized with Galactose Units
por: Kumar, Rajesh, et al.
Publicado: (2017)

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality
por: Elmén, Joacim, et al.
Publicado: (2005)

Synthesis and Biophysical Properties of C5-Functionalized LNA (Locked Nucleic Acid)
por: Kumar, Pawan, et al.
Publicado: (2014)

Locked nucleic acid (LNA): High affinity targeting of RNA for diagnostics and therapeutics
por: Kauppinen, Sakari, et al.
Publicado: (2005)

Position-dependent effects of locked nucleic acid (LNA) on DNA sequencing and PCR primers
por: Levin, Joshua D., et al.
Publicado: (2006)

Optimization of an AMBER Force Field for the Artificial Nucleic Acid, LNA, and Benchmarking with NMR of L(CAAU)
por: Condon, David E., et al.
Publicado: (2013)

Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA
por: Kumar, Pawan, et al.
Publicado: (2017)

Synthesis and biophysical properties of carbamate-locked nucleic acid (LNA) oligonucleotides with potential antisense applications
por: Thorpe, Cameron, et al.
Publicado: (2019)

An Investigation into the Potential of Targeting Escherichia coli rne mRNA with Locked Nucleic Acid (LNA) Gapmers as an Antibacterial Strategy
por: Goddard, Layla R., et al.
Publicado: (2021)

Duplex Structure of a Minimal Nucleic Acid
por: Schlegel, Mark K., et al.
Publicado: (2008)

Application of Locked Nucleic Acid (LNA) Primer and PCR Clamping by LNA Oligonucleotide to Enhance the Amplification of Internal Transcribed Spacer (ITS) Regions in Investigating the Community Structures of Plant–Associated Fungi
por: Ikenaga, Makoto, et al.
Publicado: (2016)

Down-modulation of cancer targets using locked nucleic acid (LNA)-based antisense oligonucleotides without transfection
por: Zhang, Y, et al.
Publicado: (2011)

Computational Investigation of Locked Nucleic Acid (LNA) Nucleotides in the Active Sites of DNA Polymerases by Molecular Docking Simulations
por: Poongavanam, Vasanthanathan, et al.
Publicado: (2014)

Targeting LDL Cholesterol With LNA
por: Krieg, Arthur M
Publicado: (2012)

A Locked Nucleic Acid Antisense Oligonucleotide (LNA) Silences PCSK9 and Enhances LDLR Expression In Vitro and In Vivo
por: Gupta, Nidhi, et al.
Publicado: (2010)

Novel locked nucleic acid (LNA)-based probe for the rapid identification of Chlamydia suis using real-time PCR
por: Lis, Paweł, et al.
Publicado: (2014)

In vitro and in vivo activity of miR-92a–Locked Nucleic Acid (LNA)–Inhibitor against endometrial cancer
por: Torres, Anna, et al.
Publicado: (2016)

Hybridization-Based Detection of Helicobacter pylori at Human Body Temperature Using Advanced Locked Nucleic Acid (LNA) Probes
por: Fontenete, Sílvia, et al.
Publicado: (2013)

On the stability of peptide nucleic acid duplexes in the presence of organic solvents
por: Sen, Anjana, et al.
Publicado: (2007)

Stability and Mismatch Discrimination of Locked Nucleic Acid–DNA Duplexes
por: Owczarzy, Richard, et al.
Publicado: (2011)

Thermodynamics of RNA duplexes modified with unlocked nucleic acid nucleotides
por: Pasternak, Anna, et al.
Publicado: (2010)

The structural plasticity of nucleic acid duplexes revealed by WAXS and MD
por: He, Weiwei, et al.
Publicado: (2021)

Stimulation of ribosomal frameshifting by antisense LNA
por: Yu, Chien-Hung, et al.
Publicado: (2010)

Electronic Structures of LNA Phosphorothioate Oligonucleotides
por: Bohr, Henrik G., et al.
Publicado: (2017)

LNA blockers for improved amplification selectivity
por: Prout, Jaime, et al.
Publicado: (2023)

2′,4′‐BNA/LNA with 9‐(2‐Aminoethoxy)‐1,3‐diaza‐2‐oxophenoxazine Efficiently Forms Duplexes and Has Enhanced Enzymatic Resistance
por: Kishimoto, Yuki, et al.
Publicado: (2020)

Enzymatic synthesis of DNA strands containing α-L-LNA (α-L-configured locked nucleic acid) thymine nucleotides
por: Højland, Torben, et al.
Publicado: (2012)

Erratum to: In vitro and in vivo activity of miR-92a–Locked Nucleic Acid (LNA)–Inhibitor against endometrial cancer
por: Torres, Anna, et al.
Publicado: (2016)

Compaction of Duplex Nucleic Acids upon Native Electrospray Mass Spectrometry
por: Porrini, Massimiliano, et al.
Publicado: (2017)

Locked Nucleic Acid Flow Cytometry-fluorescence in situ Hybridization (LNA flow-FISH): a Method for Bacterial Small RNA Detection
por: Robertson, Kelly L., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_ilj2kuuancusnv58vg74rm6594