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Anti-malarial activity of geldanamycin derivatives in mice infected with Plasmodium yoelii

BACKGROUND: Geldanamycin (GA), a benzoquinone ansamycin antibiotic has been shown in vitro to possess anti-plasmodial activity. Pharmacological activity of this drug is attributed to its ability to inhibit PfHSP90. The parasite growth arrest has been shown to be due to drug-induced blockage of the t...

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Detalles Bibliográficos
Autores principales:	Mout, Rubul, Xu, Zhi-Dong, Wolf, Angela K H, Jo Davisson, Vincent, Jarori, Gotam K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361485/ https://www.ncbi.nlm.nih.gov/pubmed/22361388 http://dx.doi.org/10.1186/1475-2875-11-54

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