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Posterior Circulation Stroke: Animal Models and Mechanism of Disease

Posterior circulation stroke refers to the vascular occlusion or bleeding, arising from the vertebrobasilar vasculature of the brain. Clinical studies show that individuals who experience posterior circulation stroke will develop significant brain injury, neurologic dysfunction, or death. Yet the th...

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Detalles Bibliográficos
Autores principales: Lekic, Tim, Ani, Chizobam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361739/
https://www.ncbi.nlm.nih.gov/pubmed/22665986
http://dx.doi.org/10.1155/2012/587590
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author Lekic, Tim
Ani, Chizobam
author_facet Lekic, Tim
Ani, Chizobam
author_sort Lekic, Tim
collection PubMed
description Posterior circulation stroke refers to the vascular occlusion or bleeding, arising from the vertebrobasilar vasculature of the brain. Clinical studies show that individuals who experience posterior circulation stroke will develop significant brain injury, neurologic dysfunction, or death. Yet the therapeutic needs of this patient subpopulation remain largely unknown. Thus understanding the causative factors and the pathogenesis of brain damage is important, if posterior circulation stroke is to be prevented or treated. Appropriate animal models are necessary to achieve this understanding. This paper critically integrates the neurovascular and pathophysiological features gleaned from posterior circulation stroke animal models into clinical correlations.
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spelling pubmed-33617392012-06-04 Posterior Circulation Stroke: Animal Models and Mechanism of Disease Lekic, Tim Ani, Chizobam J Biomed Biotechnol Review Article Posterior circulation stroke refers to the vascular occlusion or bleeding, arising from the vertebrobasilar vasculature of the brain. Clinical studies show that individuals who experience posterior circulation stroke will develop significant brain injury, neurologic dysfunction, or death. Yet the therapeutic needs of this patient subpopulation remain largely unknown. Thus understanding the causative factors and the pathogenesis of brain damage is important, if posterior circulation stroke is to be prevented or treated. Appropriate animal models are necessary to achieve this understanding. This paper critically integrates the neurovascular and pathophysiological features gleaned from posterior circulation stroke animal models into clinical correlations. Hindawi Publishing Corporation 2012 2012-05-14 /pmc/articles/PMC3361739/ /pubmed/22665986 http://dx.doi.org/10.1155/2012/587590 Text en Copyright © 2012 T. Lekic and C. Ani. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lekic, Tim
Ani, Chizobam
Posterior Circulation Stroke: Animal Models and Mechanism of Disease
title Posterior Circulation Stroke: Animal Models and Mechanism of Disease
title_full Posterior Circulation Stroke: Animal Models and Mechanism of Disease
title_fullStr Posterior Circulation Stroke: Animal Models and Mechanism of Disease
title_full_unstemmed Posterior Circulation Stroke: Animal Models and Mechanism of Disease
title_short Posterior Circulation Stroke: Animal Models and Mechanism of Disease
title_sort posterior circulation stroke: animal models and mechanism of disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361739/
https://www.ncbi.nlm.nih.gov/pubmed/22665986
http://dx.doi.org/10.1155/2012/587590
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