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Posterior Circulation Stroke: Animal Models and Mechanism of Disease
Posterior circulation stroke refers to the vascular occlusion or bleeding, arising from the vertebrobasilar vasculature of the brain. Clinical studies show that individuals who experience posterior circulation stroke will develop significant brain injury, neurologic dysfunction, or death. Yet the th...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361739/ https://www.ncbi.nlm.nih.gov/pubmed/22665986 http://dx.doi.org/10.1155/2012/587590 |
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author | Lekic, Tim Ani, Chizobam |
author_facet | Lekic, Tim Ani, Chizobam |
author_sort | Lekic, Tim |
collection | PubMed |
description | Posterior circulation stroke refers to the vascular occlusion or bleeding, arising from the vertebrobasilar vasculature of the brain. Clinical studies show that individuals who experience posterior circulation stroke will develop significant brain injury, neurologic dysfunction, or death. Yet the therapeutic needs of this patient subpopulation remain largely unknown. Thus understanding the causative factors and the pathogenesis of brain damage is important, if posterior circulation stroke is to be prevented or treated. Appropriate animal models are necessary to achieve this understanding. This paper critically integrates the neurovascular and pathophysiological features gleaned from posterior circulation stroke animal models into clinical correlations. |
format | Online Article Text |
id | pubmed-3361739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33617392012-06-04 Posterior Circulation Stroke: Animal Models and Mechanism of Disease Lekic, Tim Ani, Chizobam J Biomed Biotechnol Review Article Posterior circulation stroke refers to the vascular occlusion or bleeding, arising from the vertebrobasilar vasculature of the brain. Clinical studies show that individuals who experience posterior circulation stroke will develop significant brain injury, neurologic dysfunction, or death. Yet the therapeutic needs of this patient subpopulation remain largely unknown. Thus understanding the causative factors and the pathogenesis of brain damage is important, if posterior circulation stroke is to be prevented or treated. Appropriate animal models are necessary to achieve this understanding. This paper critically integrates the neurovascular and pathophysiological features gleaned from posterior circulation stroke animal models into clinical correlations. Hindawi Publishing Corporation 2012 2012-05-14 /pmc/articles/PMC3361739/ /pubmed/22665986 http://dx.doi.org/10.1155/2012/587590 Text en Copyright © 2012 T. Lekic and C. Ani. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Lekic, Tim Ani, Chizobam Posterior Circulation Stroke: Animal Models and Mechanism of Disease |
title | Posterior Circulation Stroke: Animal Models and Mechanism of Disease |
title_full | Posterior Circulation Stroke: Animal Models and Mechanism of Disease |
title_fullStr | Posterior Circulation Stroke: Animal Models and Mechanism of Disease |
title_full_unstemmed | Posterior Circulation Stroke: Animal Models and Mechanism of Disease |
title_short | Posterior Circulation Stroke: Animal Models and Mechanism of Disease |
title_sort | posterior circulation stroke: animal models and mechanism of disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361739/ https://www.ncbi.nlm.nih.gov/pubmed/22665986 http://dx.doi.org/10.1155/2012/587590 |
work_keys_str_mv | AT lekictim posteriorcirculationstrokeanimalmodelsandmechanismofdisease AT anichizobam posteriorcirculationstrokeanimalmodelsandmechanismofdisease |