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Isolated facial cutaneous sarcoidosis
Isolated cutaneous sarcoidosis is a rare multisystemic granulomatous disorder of unknown etiology. Cutaneous lesions have been classified into specific and nonspecific depending on the presence of noncaseating granulomas on histopathologic studies. Macrophages most likely initiate the response of sa...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361786/ https://www.ncbi.nlm.nih.gov/pubmed/22690059 http://dx.doi.org/10.4103/0976-9668.95980 |
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author | Kumar, Sumir Garg, Ravinder Aggarwal, Simmi Kaur, Jaskanwal |
author_facet | Kumar, Sumir Garg, Ravinder Aggarwal, Simmi Kaur, Jaskanwal |
author_sort | Kumar, Sumir |
collection | PubMed |
description | Isolated cutaneous sarcoidosis is a rare multisystemic granulomatous disorder of unknown etiology. Cutaneous lesions have been classified into specific and nonspecific depending on the presence of noncaseating granulomas on histopathologic studies. Macrophages most likely initiate the response of sarcoidosis by presenting unidentified antigens to CD4+ lymphocytes. A persistent poorly degradable antigen-driven CMI response leads to cytokine cascade, granulomaformation, and fibrosis. In the present study, we report a case of isolated cutaneous sarcoidosis, localized to the face, in an adolescent girl without systemic manifestations which is a rare entity. |
format | Online Article Text |
id | pubmed-3361786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-33617862012-06-11 Isolated facial cutaneous sarcoidosis Kumar, Sumir Garg, Ravinder Aggarwal, Simmi Kaur, Jaskanwal J Nat Sci Biol Med Case Report Isolated cutaneous sarcoidosis is a rare multisystemic granulomatous disorder of unknown etiology. Cutaneous lesions have been classified into specific and nonspecific depending on the presence of noncaseating granulomas on histopathologic studies. Macrophages most likely initiate the response of sarcoidosis by presenting unidentified antigens to CD4+ lymphocytes. A persistent poorly degradable antigen-driven CMI response leads to cytokine cascade, granulomaformation, and fibrosis. In the present study, we report a case of isolated cutaneous sarcoidosis, localized to the face, in an adolescent girl without systemic manifestations which is a rare entity. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3361786/ /pubmed/22690059 http://dx.doi.org/10.4103/0976-9668.95980 Text en Copyright: © Journal of Natural Science, Biology and Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Kumar, Sumir Garg, Ravinder Aggarwal, Simmi Kaur, Jaskanwal Isolated facial cutaneous sarcoidosis |
title | Isolated facial cutaneous sarcoidosis |
title_full | Isolated facial cutaneous sarcoidosis |
title_fullStr | Isolated facial cutaneous sarcoidosis |
title_full_unstemmed | Isolated facial cutaneous sarcoidosis |
title_short | Isolated facial cutaneous sarcoidosis |
title_sort | isolated facial cutaneous sarcoidosis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361786/ https://www.ncbi.nlm.nih.gov/pubmed/22690059 http://dx.doi.org/10.4103/0976-9668.95980 |
work_keys_str_mv | AT kumarsumir isolatedfacialcutaneoussarcoidosis AT gargravinder isolatedfacialcutaneoussarcoidosis AT aggarwalsimmi isolatedfacialcutaneoussarcoidosis AT kaurjaskanwal isolatedfacialcutaneoussarcoidosis |