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Isolated facial cutaneous sarcoidosis

Isolated cutaneous sarcoidosis is a rare multisystemic granulomatous disorder of unknown etiology. Cutaneous lesions have been classified into specific and nonspecific depending on the presence of noncaseating granulomas on histopathologic studies. Macrophages most likely initiate the response of sa...

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Autores principales: Kumar, Sumir, Garg, Ravinder, Aggarwal, Simmi, Kaur, Jaskanwal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361786/
https://www.ncbi.nlm.nih.gov/pubmed/22690059
http://dx.doi.org/10.4103/0976-9668.95980
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author Kumar, Sumir
Garg, Ravinder
Aggarwal, Simmi
Kaur, Jaskanwal
author_facet Kumar, Sumir
Garg, Ravinder
Aggarwal, Simmi
Kaur, Jaskanwal
author_sort Kumar, Sumir
collection PubMed
description Isolated cutaneous sarcoidosis is a rare multisystemic granulomatous disorder of unknown etiology. Cutaneous lesions have been classified into specific and nonspecific depending on the presence of noncaseating granulomas on histopathologic studies. Macrophages most likely initiate the response of sarcoidosis by presenting unidentified antigens to CD4+ lymphocytes. A persistent poorly degradable antigen-driven CMI response leads to cytokine cascade, granulomaformation, and fibrosis. In the present study, we report a case of isolated cutaneous sarcoidosis, localized to the face, in an adolescent girl without systemic manifestations which is a rare entity.
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spelling pubmed-33617862012-06-11 Isolated facial cutaneous sarcoidosis Kumar, Sumir Garg, Ravinder Aggarwal, Simmi Kaur, Jaskanwal J Nat Sci Biol Med Case Report Isolated cutaneous sarcoidosis is a rare multisystemic granulomatous disorder of unknown etiology. Cutaneous lesions have been classified into specific and nonspecific depending on the presence of noncaseating granulomas on histopathologic studies. Macrophages most likely initiate the response of sarcoidosis by presenting unidentified antigens to CD4+ lymphocytes. A persistent poorly degradable antigen-driven CMI response leads to cytokine cascade, granulomaformation, and fibrosis. In the present study, we report a case of isolated cutaneous sarcoidosis, localized to the face, in an adolescent girl without systemic manifestations which is a rare entity. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3361786/ /pubmed/22690059 http://dx.doi.org/10.4103/0976-9668.95980 Text en Copyright: © Journal of Natural Science, Biology and Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kumar, Sumir
Garg, Ravinder
Aggarwal, Simmi
Kaur, Jaskanwal
Isolated facial cutaneous sarcoidosis
title Isolated facial cutaneous sarcoidosis
title_full Isolated facial cutaneous sarcoidosis
title_fullStr Isolated facial cutaneous sarcoidosis
title_full_unstemmed Isolated facial cutaneous sarcoidosis
title_short Isolated facial cutaneous sarcoidosis
title_sort isolated facial cutaneous sarcoidosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361786/
https://www.ncbi.nlm.nih.gov/pubmed/22690059
http://dx.doi.org/10.4103/0976-9668.95980
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