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Inflammation & apoptosis in spinal cord injury
Spinal cord injury (SCI) consists of a two-steps process involving a primary mechanical injury followed by an inflammatory process and apoptosis. Secondary insult is characterized by further destruction of neuronal and glial cells, and leads to expansion of the damage, so that the paralysis can exte...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361863/ https://www.ncbi.nlm.nih.gov/pubmed/22561613 |
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author | Zhang, Ning Yin, Ying Xu, Sheng-Jie Wu, Yong-Ping Chen, Wei-Shan |
author_facet | Zhang, Ning Yin, Ying Xu, Sheng-Jie Wu, Yong-Ping Chen, Wei-Shan |
author_sort | Zhang, Ning |
collection | PubMed |
description | Spinal cord injury (SCI) consists of a two-steps process involving a primary mechanical injury followed by an inflammatory process and apoptosis. Secondary insult is characterized by further destruction of neuronal and glial cells, and leads to expansion of the damage, so that the paralysis can extend to higher segments. With the identification of mechanisms that either promote or prevent neuronal inflammation and apoptosis come new approaches for preventing and treating neurodegenerative disorders. From a clinical perspective, this article discusses novel targets for the development of therapeutic agents that have the potential to protect the spinal cord from irreversible damage and promote functional recovery. |
format | Online Article Text |
id | pubmed-3361863 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-33618632012-06-01 Inflammation & apoptosis in spinal cord injury Zhang, Ning Yin, Ying Xu, Sheng-Jie Wu, Yong-Ping Chen, Wei-Shan Indian J Med Res Review Article Spinal cord injury (SCI) consists of a two-steps process involving a primary mechanical injury followed by an inflammatory process and apoptosis. Secondary insult is characterized by further destruction of neuronal and glial cells, and leads to expansion of the damage, so that the paralysis can extend to higher segments. With the identification of mechanisms that either promote or prevent neuronal inflammation and apoptosis come new approaches for preventing and treating neurodegenerative disorders. From a clinical perspective, this article discusses novel targets for the development of therapeutic agents that have the potential to protect the spinal cord from irreversible damage and promote functional recovery. Medknow Publications & Media Pvt Ltd 2012-03 /pmc/articles/PMC3361863/ /pubmed/22561613 Text en Copyright: © The Indian Journal of Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zhang, Ning Yin, Ying Xu, Sheng-Jie Wu, Yong-Ping Chen, Wei-Shan Inflammation & apoptosis in spinal cord injury |
title | Inflammation & apoptosis in spinal cord injury |
title_full | Inflammation & apoptosis in spinal cord injury |
title_fullStr | Inflammation & apoptosis in spinal cord injury |
title_full_unstemmed | Inflammation & apoptosis in spinal cord injury |
title_short | Inflammation & apoptosis in spinal cord injury |
title_sort | inflammation & apoptosis in spinal cord injury |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361863/ https://www.ncbi.nlm.nih.gov/pubmed/22561613 |
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