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Inflammation & apoptosis in spinal cord injury

Spinal cord injury (SCI) consists of a two-steps process involving a primary mechanical injury followed by an inflammatory process and apoptosis. Secondary insult is characterized by further destruction of neuronal and glial cells, and leads to expansion of the damage, so that the paralysis can exte...

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Autores principales: Zhang, Ning, Yin, Ying, Xu, Sheng-Jie, Wu, Yong-Ping, Chen, Wei-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361863/
https://www.ncbi.nlm.nih.gov/pubmed/22561613
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author Zhang, Ning
Yin, Ying
Xu, Sheng-Jie
Wu, Yong-Ping
Chen, Wei-Shan
author_facet Zhang, Ning
Yin, Ying
Xu, Sheng-Jie
Wu, Yong-Ping
Chen, Wei-Shan
author_sort Zhang, Ning
collection PubMed
description Spinal cord injury (SCI) consists of a two-steps process involving a primary mechanical injury followed by an inflammatory process and apoptosis. Secondary insult is characterized by further destruction of neuronal and glial cells, and leads to expansion of the damage, so that the paralysis can extend to higher segments. With the identification of mechanisms that either promote or prevent neuronal inflammation and apoptosis come new approaches for preventing and treating neurodegenerative disorders. From a clinical perspective, this article discusses novel targets for the development of therapeutic agents that have the potential to protect the spinal cord from irreversible damage and promote functional recovery.
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spelling pubmed-33618632012-06-01 Inflammation & apoptosis in spinal cord injury Zhang, Ning Yin, Ying Xu, Sheng-Jie Wu, Yong-Ping Chen, Wei-Shan Indian J Med Res Review Article Spinal cord injury (SCI) consists of a two-steps process involving a primary mechanical injury followed by an inflammatory process and apoptosis. Secondary insult is characterized by further destruction of neuronal and glial cells, and leads to expansion of the damage, so that the paralysis can extend to higher segments. With the identification of mechanisms that either promote or prevent neuronal inflammation and apoptosis come new approaches for preventing and treating neurodegenerative disorders. From a clinical perspective, this article discusses novel targets for the development of therapeutic agents that have the potential to protect the spinal cord from irreversible damage and promote functional recovery. Medknow Publications & Media Pvt Ltd 2012-03 /pmc/articles/PMC3361863/ /pubmed/22561613 Text en Copyright: © The Indian Journal of Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhang, Ning
Yin, Ying
Xu, Sheng-Jie
Wu, Yong-Ping
Chen, Wei-Shan
Inflammation & apoptosis in spinal cord injury
title Inflammation & apoptosis in spinal cord injury
title_full Inflammation & apoptosis in spinal cord injury
title_fullStr Inflammation & apoptosis in spinal cord injury
title_full_unstemmed Inflammation & apoptosis in spinal cord injury
title_short Inflammation & apoptosis in spinal cord injury
title_sort inflammation & apoptosis in spinal cord injury
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361863/
https://www.ncbi.nlm.nih.gov/pubmed/22561613
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