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Demonstration of the metaphylactic use of gamithromycin against bacterial pathogens associated with bovine respiratory disease in a multicentre farm trial

On five commercial cattle rearing sites across Europe, a total of 802 young cattle at high risk of developing bovine respiratory disease (BRD) associated with the bacterial pathogens Mannheimia haemolytica or Pasteurella multocida and/or Mycoplasma bovis were enrolled into a multicentre, controlled...

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Autores principales: Baggott, D., Casartelli, A., Fraisse, F., Manavella, C., Marteau, R., Rehbein, S., Wiedemann, M., Yoon, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Group 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361959/
https://www.ncbi.nlm.nih.gov/pubmed/21493573
http://dx.doi.org/10.1136/vr.c6776
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author Baggott, D.
Casartelli, A.
Fraisse, F.
Manavella, C.
Marteau, R.
Rehbein, S.
Wiedemann, M.
Yoon, S.
author_facet Baggott, D.
Casartelli, A.
Fraisse, F.
Manavella, C.
Marteau, R.
Rehbein, S.
Wiedemann, M.
Yoon, S.
author_sort Baggott, D.
collection PubMed
description On five commercial cattle rearing sites across Europe, a total of 802 young cattle at high risk of developing bovine respiratory disease (BRD) associated with the bacterial pathogens Mannheimia haemolytica or Pasteurella multocida and/or Mycoplasma bovis were enrolled into a multicentre, controlled field trial. Half were treated with a single dose of gamithromycin at 6 mg/kg bodyweight by subcutaneous injection and half received an injection of a saline placebo as the control. All animals were observed daily for 14 days for signs of BRD as defined by set criteria. The proportion of metaphylactic preventive treatment successes, defined as animals surviving to day 14 without signs of BRD, in the gamithromycin-treated group (86 per cent) was significantly (P=0.0012) higher than in the saline-treated controls (61 per cent). Morbidity among the treated animals was reduced by 64 per cent compared with the controls.
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spelling pubmed-33619592012-05-31 Demonstration of the metaphylactic use of gamithromycin against bacterial pathogens associated with bovine respiratory disease in a multicentre farm trial Baggott, D. Casartelli, A. Fraisse, F. Manavella, C. Marteau, R. Rehbein, S. Wiedemann, M. Yoon, S. Vet Rec Research On five commercial cattle rearing sites across Europe, a total of 802 young cattle at high risk of developing bovine respiratory disease (BRD) associated with the bacterial pathogens Mannheimia haemolytica or Pasteurella multocida and/or Mycoplasma bovis were enrolled into a multicentre, controlled field trial. Half were treated with a single dose of gamithromycin at 6 mg/kg bodyweight by subcutaneous injection and half received an injection of a saline placebo as the control. All animals were observed daily for 14 days for signs of BRD as defined by set criteria. The proportion of metaphylactic preventive treatment successes, defined as animals surviving to day 14 without signs of BRD, in the gamithromycin-treated group (86 per cent) was significantly (P=0.0012) higher than in the saline-treated controls (61 per cent). Morbidity among the treated animals was reduced by 64 per cent compared with the controls. BMJ Group 2011-02-28 /pmc/articles/PMC3361959/ /pubmed/21493573 http://dx.doi.org/10.1136/vr.c6776 Text en British Veterinary Association This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.
spellingShingle Research
Baggott, D.
Casartelli, A.
Fraisse, F.
Manavella, C.
Marteau, R.
Rehbein, S.
Wiedemann, M.
Yoon, S.
Demonstration of the metaphylactic use of gamithromycin against bacterial pathogens associated with bovine respiratory disease in a multicentre farm trial
title Demonstration of the metaphylactic use of gamithromycin against bacterial pathogens associated with bovine respiratory disease in a multicentre farm trial
title_full Demonstration of the metaphylactic use of gamithromycin against bacterial pathogens associated with bovine respiratory disease in a multicentre farm trial
title_fullStr Demonstration of the metaphylactic use of gamithromycin against bacterial pathogens associated with bovine respiratory disease in a multicentre farm trial
title_full_unstemmed Demonstration of the metaphylactic use of gamithromycin against bacterial pathogens associated with bovine respiratory disease in a multicentre farm trial
title_short Demonstration of the metaphylactic use of gamithromycin against bacterial pathogens associated with bovine respiratory disease in a multicentre farm trial
title_sort demonstration of the metaphylactic use of gamithromycin against bacterial pathogens associated with bovine respiratory disease in a multicentre farm trial
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361959/
https://www.ncbi.nlm.nih.gov/pubmed/21493573
http://dx.doi.org/10.1136/vr.c6776
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